摘要
目的探讨外源性神经生长因子(nerve growth factor,NGF)治疗中重度新生儿缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)的临床疗效及其对血清NSE和S-100B蛋白的影响。方法将58例中重度HIE新生儿随机分为两组,在基础治疗上,常规对照组加用脑蛋白水解物(脑活素),而NGF治疗组尽早(生后24 h内)应用鼠NGF。观察两组患儿治疗后的NBNA评分和随访1年后智能发育商(DQ)及血清NSE和S-100B蛋白的变化。另取12例正常新生儿作为治疗前正常对照。结果 NGF治疗组的NBNA评分及DQ正常率均明显高于常规对照组(p<0.05),治疗前两组HIE患儿血清NSE及S-100B水平均显著高于正常对照组(p<0.01),治疗3 d及7 d后NGF治疗组血清NSE及S-100B明显低于常规对照组(p<0.05)。结论外源性神经生长因子治疗新生儿HIE,可以减少NSE及S-100B的释放,发挥神经保护作用。
Objective To explore the efficacy of nerve growth factor（NGF） on neonates with moderate and sever hypoxic-ischemic encephalopathy（HIE） and its influence on serum NSE and S-100β protein. Methods 58 inpatients with moderate and sever neonatal HIE in our Neonatal Department were randomly divided into NGF treatment group and routine treatment group.In addition to individualized supportive treatment,the routine treatment group was treated with cerebrolysin,the NGF treatment group was given NGF as early as possible（within twenty-four hours after birth）.What′smore,observed the changes of NBNA score,one year intellectual development quotient,NSE,S-100B protein after treatment.And 12 cases of normal newborns were selected as healthy control group. Results NBNA score and the nornlal rate of intellectual development quotient in NGF treatment group were significantly higher than those of routine treatment group（p0.05）.The levels of NSE and S-100B in two treatment groups were significant higher than those of healthy control group（p0.01）.The levels of NSE and S-100B at 3d and 7d after treatment in NGF treatment group were significant lower than those of routine treatment group（p0.05）. Conclusion Nerve growth factor may reduce NSE and S-100B rerease and exert neuroprotection in neonates with HIE.
出处
《现代医院》
2012年第4期19-22,共4页
Modern Hospitals
