摘要
目的 探讨肾移植后应用他克莫司 (FK5 0 6 )的方法、剂量、疗效及副作用。方法 30例尸肾移植患者术后应用他克莫司 ,临床观察 3个月 ,监测血中他克莫司的浓度和副作用。结果 30例患者术后肾功能均恢复正常 ,在应用他克莫司的观察期内无排斥反应发生 ;血中他克莫司的浓度 ,3例为 5～ 7μg/L ,2 5例为 8～ 15 μg/L ,2例为 32～ 38μg/L ;他克莫司的副作用主要为骨髓抑制和血糖升高。结论 他克莫司是一种强效免疫抑制剂 ;用药要个体化 ,不应片面强调他克莫司的血药浓度 ;他克莫司适合慢性肝炎或肝功能损害者使用 ;
Objectives To summarize the experiences of clinical use of tacrolimus as an alternative to cyclosporin in cadaver renal transplantation. Methods Blood concentrations and side effects of tacrolimus were observed for 3 months in 30 cases of cadaver renal transplantation. Results Renal functions were returned to normal in the 30 cases after operation. No rejection occurred during the application of tacrolimus. The blood concentrations of tacrolimus were 5～7?μg/L in 3 cases, 8～15?μg/L in 25 cases and 32～38?μg/L in 2 cases, respectively. The main side effects of tacrolimus including marrow depression and hyperglycemia. Conclusions Tacrolimus is a highly effective immunosuppressive agent. When blood trough concentrations of tacrolimus are relatively low in the patients with normal renal function, there is no need to increase the dosage of tacrolimus. Tacrolimus is less harmful to liver and may be the best choice as an immunosuppressive therapy for patients with chronic hepatitis or abnormal liver function.
出处
《中华器官移植杂志》
CAS
CSCD
2000年第3期147-148,共2页
Chinese Journal of Organ Transplantation
关键词
肾移植
免疫抑制剂
治疗结果
药物毒性
他克莫司
Kidney transplantation
Immunosuppressive agents
Treatment outcome
Drug toxicity
