摘要
为了研究胆红素对急性运动所致氧化应激的保护作用，将Ｗｉｓｔａｒ大鼠随机分为对照组、运动组、运动恢复组、胆红素处理运动组、胆红素处理运动恢复组，共５组，分别灌胃生理浓度的胆红素或生理盐水４周，负重（体重的５％）游泳２小时后处死，测定有关的指标。结果表明，生理浓度的胆红素能抑制运动后血清和用）肠肌匀浆丙二醛（ＭＤＡ）含量的升高，抑制运动后超氧化物歧化酶（ＳＯＤ）活性的下降，同时也可以减少运动后氧自由基的产生并降低体内自发产生的氧自由基，提示胆红素具有一定的抗运动所致氧化应激的作用。
In order to study the oxidative stress in acute exercise and the inhibitive effect of bilirubin, animal experiment was performed. 41 Wisteria male rats were divided into five groups, that is control group, exercise group, exercise recovery group, bilirubin -treated ex- excise group and bilirubin - treated exercise recovery group. The rats were administrated with lμmoll/kg body weight of bilinbin or saline once every day for 4 weeks, father swimming with load(5% of body weight) for 2h, all of the rats were killed and several index were determined. The results showed that oxygen free radicals could be produced in the skeletal muscle of rats in the process of acute exercise, and these free radicals could be scavenged by bililubin. Bilirubin may also inhibit MDA increase and SOD decrease induced by acute exercise, suggesting that treatment with bilirubin to rats for a long time may decrease the oxidative stress induced by acute exercise.
出处
《中国运动医学杂志》
CAS
CSCD
北大核心
2000年第2期150-152,共3页
Chinese Journal of Sports Medicine
