摘要
目的探讨甲泼尼龙静脉推注联合氨溴索、布地奈德雾化吸入治疗慢性阻塞性肺疾病(COPD)急性加重期的临床效果。方法 120例COPD急性加重期患者随机分为治疗组和对照组,每组各60例。治疗组在常规治疗的基础上给予甲泼尼龙静脉推注联合氨溴索、布地奈德雾化吸入治疗,对照组仅予甲泼尼龙静脉推注治疗。观察两组临床效果和不良反应。结果治疗后两组肺功能均得到改善,IgA、IgG均明显升高,且治疗组改善情况均优于对照组,差异均有统计学意义(P<0.05);治疗组总有效率高于对照组,不良反应发生率低于对照组,差异均有统计学意义(P<0.05)。结论甲泼尼龙静脉推注联合氨溴索、布地奈德雾化吸入治疗COPD急性加重期能有效缩短COPD急性发作的时间,有助于肺功能的快速改善,简单、安全有效。
Objective To investigate clinical efficacy of Methylprednisolone intravenous injection and Ambroxol,inhalation of Budesonide for the treatment of chronic obstructive pulmonary disease（COPD） in an acute exacerbation period.Methods 120 patients of acute exacerbation of COPD patients were randomly divided into a treatment group and control group（60 patients in each group）.On the basis of conventional treatment,the treatment group was treated with Methylprednisolone intravenous injection and inhalation of Ambroxol,and Budesonide.The control group was only treated with Methylprednisolone intravenous injection.The clinical efficacy and adverse effects were observed in both groups.Results Patients in these two groups had improvement in pulmonary function,and the levels of IgA and IgG were significantly increased after treatment,and the effect in treatment group was better than that in the control group,and the difference were statistically significant（P0.05）.The overall efficacy in the treatment group was higher than that in the control group,while the incidence rate of adverse reaction in treatment group was lower than that in control group,and the difference was statistically significant（P0.05）.Both groups had fluid and electrolyte imbalance,elevated blood glucose,fungal infection,insomnia and other adverse reactions.Conclusion Intravenous injection of Methylprednisolone and inhalation of Ambroxol,and Budesonide can be used to treat acute exacerbation of COPD,which can effectively shorten the recovery time in COPD patients with acute exacerbation,and rapidly improve lung function,proven to be safe and effective.
出处
《解放军医药杂志》
CAS
2012年第4期34-36,共3页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
广西梧州市科研项目(201102026)
关键词
甲泼尼龙
氨溴索
布地奈德
肺疾病
慢性阻塞性
治疗结果
Methylprednisolone
Ambroxol
Budesonide
Pulmonary disease
chronic obstructive
Treatment outcome
