摘要
目的探讨纤维蛋白原在颅外段颈动脉重度狭窄所致脑梗死中的作用。方法对重度颈动脉狭窄导致脑梗死患者83例,无症状的颈动脉狭窄患者35例及健康查体者50例(作为对照组)均测定纤维蛋白原含量,分析它们之间的关系,并分析纤维蛋白原含量与狭窄后脑梗死类型、神经功能缺失程度及预后的关系。结果梗死组纤维蛋白原水平明显高于无症状狭窄组及健康对照组,区域性脑梗死的纤维蛋白原水平明显高于其他各型(P<0.05),纤维蛋白原水平越高神经功能缺失程度越重,且其水平越高,预后越差。结论纤维蛋白原增高与重度颈动脉狭窄及其所致脑梗死密切相关,支持特定的梗死类型,可能对病情的严重程度和预后有预示作用。
Objective To study the level of fibrinogen in the blood of patients with cerebral infarction caused by severe extracranial carotid artery stenosis and to explore the significance to guide the clinical diagnosis and treatment. Methods 83 patients with acute cerebral infarction,among them,35 patients with asymptomatic severe carotid artery stenosis and 50 healthy volunteers（as a control group）were selected,and their fibrinogen level was tested to find the difference among them and the rele- vance with cerebral infarction types,the degree of neurologic function defect,and state of stroke. Results The fibrinogen level of the cerebral infarction group was significantly higher than asymptomatic severe carotid artery stenosis group and control group. The fibrinogen level of regional cerebral infarction was significantly higher than the others＇ （P 〈 0.05 ）. The higher level of the fi- brinogen,the heavier deficit of the neurologic and the worse prognosis. Conclusion The level of fibrinogen is closely related to severe carotid artery stenosis and cerebral infarction caused by severe carotid artery stenosis, which supports specific infarction type and can indicate the severity and prognosis of the illness.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2012年第5期426-429,共4页
Journal of Apoplexy and Nervous Diseases
关键词
纤维蛋白原
重度颈动脉狭窄
脑梗死
Fibrinogen
Severe carotid artery stenosis
Cerebral infarction
