摘要
目的:探讨Survivin、Bcl-2、PCNA在乳腺癌中的表达及临床意义。方法:应用免疫组织化学方法,检测60例乳腺癌Survivin、Bcl-2、PCNA的表达,分析其相关性。结果:Survivin、Bcl-2、PCNA在乳腺癌中表达阳性率分别为70.00%(42/60)、66.67%(40/60)和71.67%(43/60)。Survivin表达与年龄、组织学分级无显著相关(P>0.05),与淋巴结转移呈显著相关(P<0.05);Bcl-2表达与年龄无显著相关(P>0.05),与组织学分级、淋巴结转移呈显著相关(P<0.05);PCNA与Survivin、Bcl-2之间差异有统计学意义(P<0.05)。结论:Survivin、Bcl-2的表达与乳腺癌的各临床病理指标密切相关,可能是判断其预后的重要指标,但与临床、病理和预后等各参数的内在联系有待进一步研究。
Objective： To explore the expressions and clinical significances of Survivin, Bcl -2, and PCNA in breast cancer. Methods： Immunohistochemical method was applied to detect the expression rates of Survivin, Bcl - 2, and PCNA in 60 cases with breast cancer, then the correlation was analyzed. Results： The positive expression rates of Survivin, Bcl -2, and PCNA in breast cancer were 70. 00% （42/60） , 66. 67% （40/60） , and 71.67% （43/60） , respectively. There was no significant correlation between Survivin expression and age, histological grade （ P 〉 0. 05 ） , but Survivin expression was significantly correlated with lymph node metastasis （ P 〈 0. 05 ） . There was no significant correlation between Bcl - 2 expression and age （ P 〉 0.05 ） , but Bcl - 2 expression was significantly correlated with histological grade and lymph node metastasis （ P 〈 0.05） . There was significant correlation between PCNA expression and Survivin expression, Bcl - 2 expression （P 〈 0. 05 ） . Conclusion： The expressions of Survivin and Bcl - 2 are related to clinicopathological characteristics of breast cancer closely, which may be important indexes to predict the prognosis, but the interral relationship with clinical parameters, pathological parameters, and prognostic parameters needs further studies.
出处
《中国妇幼保健》
CAS
北大核心
2012年第17期2670-2672,共3页
Maternal and Child Health Care of China
