摘要
目的探讨钛表面磷酸化处理的方法，并观察磷酸化钛表面在模拟体液内进行仿生矿化的实验效果，以期为钛种植体表面改性提供新的研究思路。方法用磷酸对钛表面进行酸蚀处理，再以此为仿生模板进行体外仿生矿化研究。结果钛磷酸化处理后形成粗糙、多孔的表面，再经高温高压处理，生成与钛表面化学键合的Ti（H2PO4）3晶体层，此层富含-OH及-PO4^3-离子，具备生物矿化诱导功能，从而活化钛种植体表面。结论磷酸酸蚀可以实现对钛种植体表面的磷酸化改性。
Objective To suggest a chemical surface treatment for titanium and to initiate the formation of hydroxycarbonated apatite （HCA） on titanium surface during in vitro bioactivity tests in simulated body fluid（SBF）. Methods To improve the bone-bonding ability of Ti implants, commercially pure titanium （cpTi） by a simple chemical pre-treatment in orthophosphoric acid （ H3 PQ ） with different density was activated, and then the phosphorylation specimens were soaked in SBF to investigate the function of biomineralization. Results The scanning electron microscope （SEM） photographs showed that the surfaces of the pre-treated samples were characterized by a complex construction, which consisted of a mesh- like morphology matrix （a micro-roughened surface） and an uniform surface with different morphous of titanium dihydrogen orthophosphate [ Ti （H2PO4 ）3] crystal. After 14 days in SBF a homogeneous biomimetic apatite layer precipitated. Conclusions These data suggest that the treatment of titanium by acid etching in orthophosphoric acid is a suitable method to provide the titanium implant with bone-bonding ability.
出处
《中华口腔医学杂志》
CAS
CSCD
北大核心
2012年第6期354-358,共5页
Chinese Journal of Stomatology
基金
国家自然科学基金（81170993）
安徽省教育厅自然科学重点科研项目计划（KJ2010A182）
关键词
牙种植体
钛
磷酰化
矿化
Dental implants
Titanium
Phosphorylation
Mineralization
