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Plk1与人类肿瘤生成 被引量：2

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摘要 人类肿瘤生成过程主要表现为细胞生长的失调控,而Plk1是细胞周期进行有丝分裂、胞质分裂及DNA损伤反应的关键调节因子。通过对Plk1在中心体周期中作用的认识,推测在多种癌症中可检测到Plk1表达的失控,且与人类肿瘤生成有关。研究发现,Plk1在人类多种肿瘤中存在高表达,且其高表达与肿瘤患者的细胞增殖及预后相关。应用不同方法下调Plk1的表达水平在体外细胞培养及活体动物实验中均被证实有抑制肿瘤细胞增殖及促进其凋亡的作用,但对正常细胞却无明显杀伤。因此,靶向作用于Plk1的治疗可能成为人类肿瘤治疗的新的很有潜力的方法。
作者 孙威 陈爱山 闫兆鹏 曹献馗 刘宝林
机构地区 中国医科大学附属盛京医院结直肠肛门病外科
出处 《现代肿瘤医学》 CAS 2012年第6期1300-1303,共4页 Journal of Modern Oncology
关键词 PLK1 肿瘤生成 抑癌基因 肿瘤治疗
分类号 R730.22 [医药卫生—肿瘤]
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参考文献13

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二级参考文献10

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共引文献5

同被引文献54

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现代肿瘤医学
2012年 第6期

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