摘要
组蛋白乙酰化修饰是一种重要的蛋白质翻译后修饰方式,由组蛋白乙酰基转移酶HATs和组蛋白去乙酰化酶HDACs共同调节。昆虫HDACs蛋白家族根据其同源性和结构的不同共分为4类,各昆虫物种之间既具有较高的保守同源性,同时也表现出一定的物种特异性。HDACs主要参与昆虫的胚胎发育、体节形成、寿命和神经行为等方面的调节。本文从HDACs蛋白的种类、系统发育、生理功能等方面展开,介绍了近年来国内外昆虫HDACs领域的最新研究进展,以期对研究昆虫表型可塑性调节机制以及探索新的害虫防治方法提供借鉴。
Histone acetylation is mainly regulated by histone acetyhransferases （HATs） and histone deacetylases （HDACs）. Insect HDACs can be divided into four classes according to their protein structure and sequence homology. The members of the HDACs family show highly conservative homology and species specificity. Recent research has revealed that HDACs are mainly involved in the regulation of a variety of developmental processes, including embryonic development, somite formation and patterning, life-span and neural behavior. Here, we summarize recent advances in research on insect HDACs with respect to HDACs sub-classes, phylogeny and physiological functions. Such knowledge will be beneficial for research on phenotype plasticity and pest control in insects.
出处
《应用昆虫学报》
CAS
CSCD
北大核心
2012年第3期770-777,共8页
Chinese Journal of Applied Entomology
基金
国家自然科学基金(31000980)
