摘要
MicroRNA(miRNA)是新发现的参与高等生物基因表达调控的重要分子,很多新的证据显示miRNA在免疫功能的调控方面占据着举足轻重的地位。系统性红斑狼疮(systemic lupus erythematosus,SLE)是自身免疫性疾病的原型,它以抗核抗体为代表的自身抗体的产生、免疫复合物沉积及多系统损害为特征。SLE的发病机制长期以来是风湿免疫研究领域的难点。本文综述目前所知的与系统性红斑狼疮发病机制相关的microRNA。
MicroRNA（miRNA） is a significant molecule which involves in regulating the gene expression of human being. Many evidences show that miRNA plays an important role of the regulation of immune function. Systemic lupus erythematosus（SLE）, a prototype of the autoimmune disease, characterizes by the presence of autoantibodies against numerous self-antigens including ehromatin, ribonueleoproteins, and phospholipids. The pathogenesis of SLE has long been a difficult field of Rheumatology. This paper reviews the current knowledge of the role of miRNA in the pathogenesis of svsternic luous ervthematosus.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2012年第6期534-537,共4页
Immunological Journal
基金
国家自然科学基金面上项目(30971632)
国家自然科学基金杰出青年基金(81025016)
上海市科委重点项目(10JC1409300,09411951800)
