摘要
目的:观察富血小板血浆(platelet-rich plasma,PRP)直接盖髓后修复性牙本质的形成。方法:成年雄性健康杂种犬2只,分别取静脉血制备PRP后,选取每只犬的所有切牙,尖牙和前磨牙共48个牙作为对象,于颈部制作穿髓模型后,按拆分口设计原则随机分为6组(MTA、Dycal、MTA+PRP、Dycal+PRP、PRP、空白),分别用相应盖髓剂进行直接盖髓治疗,3个月后应用牙科CT观察各组穿髓处硬组织和牙本质桥形成情况。结果:实验3个月后,MTA,MTA+PRP,Dycal+PRP组修复性牙本质形成的效果均优于单纯氢氧化钙组(Dycal)。PRP组、空白组无完整的牙本质桥形成。结论:PRP+Dycal能促进犬富血小板血浆牙髓组织修复,是一种很有希望的复合型生物盖髓剂。
AIM： To observe the formation of reparative dentin after direct pulp capping with platelet rich plasma （PRP）. METHODS： Venous blood was taken from two adult male mongrel dogs to prepare PRP. A total of 48 teeth, including all incisors, canines and premolars, were drilled to expose pulps at the neck. A split-mouth design and intra animal side randomization were applied to divide the teeth int 6 groups. The pulp was directly capped with capping agents （ MTA, Dycal, MTA ＋ PRP, Dycal ＋ PRP, PRP and blank） respectively. Three months after capping, the hard tissue and dentin bridge formation were evaluated at the exposed pulp by Dental CT. RESULTS： Reparative dentin formation in MTA, MTA ＋ PRP and Dycal ＋ PRP groups were significantly enhanced as compared with calcium hydroxide only group （Dycal）. No complete dentin bridge was formed in PRP group and blank group. CONCLU- SION ： PRP plus Dycal can promote the regeneration of dog pulp tissues, and shows promising results as a biological pulp capping agent.
出处
《牙体牙髓牙周病学杂志》
CAS
北大核心
2012年第5期284-287,共4页
Chinese Journal of Conservative Dentistry
基金
陕西省社发攻关项目基金资助(2011k14-03-07)
关键词
盖髓剂
修复性牙本质
犬
盖髓
MTA
富血小板血浆
pulp capping agent
reparative dentin
dog
pulp capping
Mieral Trioxide Aggregate （ MTA ）
platelet rich plasma （PRP）
