摘要
目的分析山西省山阴县地方性砷中毒（地砷病）病区人群唾液中砷含量，比较其与尿砷、水砷的关系．探讨唾液砷作为砷暴露标志物的可行性。方法在山西省山阴县地砷病病区抽取4个病村的70名常住居民作为调查对象，地砷病皮肤病变按《地方性砷中毒诊断标准））（WS／T211-2001）进行诊断。入户采集所有调查对象唾液、尿液及生活用水，利用电感耦合-等离子体质谱（ICP—MS）检测唾液及尿液砷含量，AFS-230原子荧光分光光度计检测水砷含量。结果在收集的水样中，水砷中位数为127．22ug/L，超标率达．66．67％（28／42），70名居民中有37人有皮肤症状。不同水砷暴露组间唾液砷与尿砷含量组间比较有统计学意义（F=28．643、10．226，P均〈0．05）。水砷与唾液砷及尿砷之间均存在明显的正相关（r=0．674、0．686，P均〈0．05）。唾液砷与尿砷之间也存在高度相关（r=0．794，P〈0．05）。另外，唾液砷、水砷、尿砷与皮肤症状均密切相关，有症状组与无症状组间三者含量差异均有统计学意义（t=-3．194、-4．167、-4．938，P均〈0．01）。结论人群唾液中砷含量与水砷暴露程度呈明显正相关，并且与砷中毒皮肤症状密切相关，提示唾液砷也可以反映人群砷暴露程度，也是一种砷暴露标志物。
Objective To investigate the arsenic level in saliva and its relationship with arsenic in urine and drinking water in endemic arsenism area in Shanyin county of Shanxi province. Methods Seventy individuals from four villages in endemic arsenicosis area in Shanyin county Shanxi provence were selected as research subjects. ＂The National Diagnosis Standard for Endemic Arsenism＂ （WS/T211-2001） was used to identify and categorize the cases of arsenicosis during the survey. Urine, saliva samples from all individuals and water samples from their families were collected. Total arsenic in saliva, urine and drinking water samples were detected by inductively coupled plasma mass spectrometry （ICP-MS） and atomic fluorescence spectrometry-230 （AFS-230）. Results The median of arsenic in drinking water samples was 127.22 ug/L, and 66.67% （28/42） of samples＇ arsenic levels exceeded the drinking water standard, 37 individuals had varying degrees of skin lesions among the 70 residents. There was a significant difference of the arsenic concentration in saliva and urine of the residents exposed to different levels of arsenic in drinking water （F = 28.643, 10.226, all P 〈 0.05）. Arsenic levels were positively correlated significantly （r = 0.674, 0.686, all P〈 0.05） between water and saliva, urinary. Saliva and urinary arsenic levels were highly correlated （r = 0.794, P 〈 0.05）. In addition, arsenic in saliva and urine, water arsenic, skin symptoms were closely related, and the levels of arsenic were significantly different statistically between symptomatic group and asymptomatic group （t = - 3.194, - 4.167, - 4.938, all P 〈 0.01）. Conclusions Salivary arsenic is significantly correlated with water arsenic and also with skin symptoms of patients with arsenic poisoning, which suggests that salivary arsenic is a potential useful biomarker for assessing human exposure to arsenic.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2012年第3期267-270,共4页
Chinese Jouranl of Endemiology
基金
基金项目：日本文部科学省日本学术振兴会研究辅助金资助项目（20390173）
苏州大学国家自然科学基金预研项目（Q3126982）
关键词
砷中毒
唾液
尿
水
皮肤
Arsenic poisning
Salivary
Urine
Water
Skin
