摘要
目前绝大多数的肿瘤耐药机制研究均集中于肿瘤细胞基因和蛋白水平,而对肿瘤组织微环境的关注则相对较少。恶性实体瘤实际上是一个类似于器官的异质性实体结构,肿瘤组织微环境中的理化因子,例如肿瘤局部pH值、血流、压力和氧供等,均会对药物的疗效产生重要的影响。上述现象被定义为"生理性耐药",其不同于信号通路或蛋白表达改变所引起的耐药。本文将重点介绍肿瘤组织局部pH值变化引起的耐药,即pH依赖性生理性耐药(pH-induced physiological drugresistance,PIPDR)的产生及其临床意义。
For the present studies in the field of oncology,most of them concentrate on cellular or genetic changes of cancer cells,but few attention is paid on the microenvironment of tumor tissues.Solid tumors are organ-like structures that are heterogeneous and structurally complex.The altered physicochemical factors in the tumor microenvironment play a vital role in the resistance to anticancer drugs,such as pH,blood flow,interstitial pressure and oxygen supply.This phenomenon is defined as ＂physiological drug resistance＂,which is distinct from the ＂biochemical drug resistance＂ caused by the altered signaling pathway or expression of proteins.This paper focuses on the drug resistance caused by altered pH value in microenvironment of tumors which is defined as pH-induced physiological drug resistance（PIPDR）,and its clinical implications.
出处
《肿瘤》
CAS
CSCD
北大核心
2012年第5期384-388,共5页
Tumor
基金
国家自然科学基金资助项目(编号:81071815
81101751)
2010年南京市科技发展计划项目(编号:201001137)
南京市卫生局2010年度市医学科技发展项目(编号:YKK10070)
关键词
抗药性
肿瘤
纳米粒子
质子泵抑制剂
Drug resistance
neoplasm
Nanoparticles
Proton pump inhibitors
