摘要
目的:分析ZnF23 mRNA在卵巢癌组织和细胞中的表达情况,以探讨其与细胞凋亡的关系。方法:采用实时荧光定量RT-PCR法检测22例卵巢癌患者癌组织和其癌旁正常组织中ZnF23表达水平。结果:22例卵巢癌患者癌组织及其癌旁正常组织标本中ZnF23相对表达量(ZnF23/GAPDH)分别为(0.2±0.15)和(1.0±0.1),差异有统计学意义(P<0.05)。结论:卵巢癌患者中ZnF23蛋白表达水平显著下降,可能与卵巢癌的发生发展有密切的关系。
Objective：To detect the expression level of zinc finger 23 mRNA in ovarian cancer tissue and cell samples investigate the relationship between ZnF23 expression and cell apoptosis.Method：The expression levels of ZnF23 in 22 cases of ovarian cancers tissue and adjacent normal ovaries were measured by real-time PCR.Results：The relation expression levels of ZnF23 mRNA in 22 ovarian cancer tissue and adjacent normal ovaries were（0.2±0.15）,（1.0±0.1）,respectively.There was significant difference between groups（P0.05）.Conclusion：The level of ZnF23 in ovarian cancers was greatly down-regulated compared with that in the normal ovaries.ZnF23 might be a potential relation of the development for ovarian cancers.
出处
《内蒙古医学杂志》
2012年第3期265-267,共3页
Inner Mongolia Medical Journal
