摘要
目的探讨高压氧对持续性植物状态（PVS）患者康复治疗的效果和作用机制。方法采用高压氧加常规治疗对62例PVS患者进行治疗。（1）高压氧治疗：采用高压氧气舱，空气加压0．18～0．20MPa。用面罩接氧气呼吸器后吸氧30rain、共2次，中间休息10min。每日1次，10次为1个疗程，平均4～6疗程。（2）常规治疗：所有患者在高压氧治疗的同时均给予药物治疗，包括止血、脱水、抗感染、神经细胞营养剂、促醒剂及对症支持疗法。按病程长短分为A组（26～59d）26例、B组（60～119d）24例和C组（120—268d）12例共3组，观察分析不同病程与高压氧疗效的关系。结果经高压氧加常规治疗后，PVS患者基本痊愈27例（43．5％），明显好转18例（29．0％），好转8例（12．9％），无效9例（14．5％），总有效率达85．5％（53／62）。高压氧加常规治疗的疗效与患者的病程长短有关，3组不同病程患者疗效（A组96．2％，B组为62．5％，C组41．7％）之间差异有统计学意义（Х^2=24．83，P〈0．01），PVS患者病程越短疗效越好。结论高压氧加常规治疗能促进持续性植物状态患者苏醒和生命功能的维持。
Objective To investigate the efficacy and mechanism of hyperbaric oxygen combining conventional therapy on persistent vegetative state （ PVS ）. Methods Sixty-two cases of PVS patients were treated with hyperbaric oxygen （ HBO ） combining with conventional therapy. （ 1 ） Hyperbaric oxygen therapy ： hyperbaric oxygen chamber was adopted and the air pressure was 0. 18 - 0. 20 MPa. The patients breathed pure oxygen for 30 min,2 times per day with a 10 rain interval, and continued for 10 days as a course with an average of 4 to 6 courses. （2）Conventional therapy ： All patients received drug treatment in hyperbaric oxygen therapy at the same time, including hemostasis, dehydration, anti-infection, nerve cell nutrition agents, wake promoting agents and supportive therapy. All patients were divided to three groups according to the course of disease ：26 - 59 days in A group,60- 119 days in B group,120 -268 days in C group,and the relationship between disease course and HBO treatment efficacy was analyzed. Results After HBO combining conventional therapy,27 cases （43.5 % ） were recovered, 18 cases （ 29. 0% ） had obvious effect, 8 cases （ 12. 9% ） had effect, 9 cases （ 14. 5 % ） were inefficacy. The efficiency related to the course of disease. The total efficiency rate was 85.5%. The efficacy of HBO treatment had significant difference in A,B and C group（96. 2% ,62. 5% and 41.7% in A,B and C group respectively, X^2 = 24. 83, P 〈 0. 01 ）. The shorter course indicated the better efficacy. Conclusion Hyperbaric oxygen combining conven.
出处
《中国综合临床》
2012年第6期639-641,共3页
Clinical Medicine of China
关键词
高压氧
颅脑外伤
持续性植物状态
Hyperbaric oxygen
Traumatic brain injury
Persistent vegetative state
