摘要
目的了解医院儿科肾病综合征免疫抑制剂用药趋势,评价用药合理性,促进临床药师更好地参与儿科合理用药。方法利用合理用药(PASS)软件系统,调出医院儿科2010年7至9月确诊为肾病综合征入院患者的疾病及用药信息,以国家卫生部《糖皮质激素类药物临床应用指导原则》《儿童常见肾脏疾病诊治循证指南》为评价标准。结果医院治疗肾病综合征的主要药物为糖皮质激素,且用药剂量和疗程均符合要求。由于该疾病易产生激素耐药,因此临床常将激素与其他免疫抑制剂联用或单用免疫抑制剂。数据分析显示,儿科应用免疫抑制剂时采取了个体化治疗,在不同治疗阶段给予合适的、不同剂量的免疫抑制剂,联合使用免疫抑制剂时也选择不同作用位点的免疫抑制剂。结论从用药趋势和经验看,除糖皮质激素之外,他克莫司和雷公藤多苷是儿科治疗肾病综合征常用的免疫抑制剂,是具有良好前景的、有效的新型免疫抑制剂。
Objective To understand the drug use trend of immunosuppressive agents in pediatric nephrotic syndrome and to evaluate the rationality of drug use for promoting the clinical pharmaciststo better participate in pediatric rational drug use. Methods The rational medication PASS software system was adopted to access the medication information of the pediatric patients diagnosed with nephrotic syn- drome from July to September 2010. ＇The Clinical Application Guidelines of Gglucocorticosteroid＇ and the ＇Evidence Based Guideline of Common Renal Diseases in Children formulated＇ by the Ministate of Public Health were used as the evaluation standard. Results The main drug for treating nephrotic syndrome was glucoeorticoid, its dosage and course conformed to the requirements. Because the disease is easy to generate glucocorticoid resistance,other immunosuppressants are often used alone or combined with glucocorticoid. The data analysis showed that pediatric immunosuppressant application adopted the individuation treatment according to different stages of the dis- ease. Combination of immunosuppressants also choose drugs affecting different locus. Conclusion From the drug use trend and experi- ence, besides glucocorticoid, tacrolimus and tripterygium glucosides are common immunosuppressants in pediatric nephrotic syndrome and have become the promising effective ways to treat nephrotic syndrome.
出处
《中国药业》
CAS
2012年第10期57-58,共2页
China Pharmaceuticals
关键词
儿童
肾病综合征
免疫抑制剂
用药分析
children
nephrotic syndrome
immunosuppressant
medication analysis
