摘要
目的探讨血浆同型半胱氨酸水平对脑梗死的影响。方法采用高效液相色谱仪HPLC-FD法检测40例急性脑梗死患者的血浆Hcy,采用离子捕获法测定患者叶酸(Fol)、维生素B12(VitB12)等指标,与40名健康对照者比较。结果 脑梗死组血浆Hcy水平和甘油三酯(TG)明显高于对照组,而Fol及VitB12水平则低于对照组,差异有统计学意义(P<0.05)。高Hcy血症与脑梗死相关,相对危险度OR为8.921(95%CI 2.16~30.32),脑梗死组和对照组血浆Hcy水平与血Fol、VitB12水平均呈显著负相关。结论 高同型半胱氨酸血症是脑梗死的独立危险因素。
Objective To research the relationship of cerebral infarction and the plasma homocysteine level.Methods Forty patients with cerebral infarction and 40 controls were studied.The plasma Hcy levels were measured by high-performance liquid chromatography-fluorescence detection(HPLC-FD).The level of Folate and Vitamin B12 were measured by trappedion method.Results The mean levels of plasma homocysteine and TG were higher in cerebral infarction patients than that in control,but the levels of plasma Fol and VitB12 were lower than that in control(P0.05).Hyperhomocysteinemia was associated with increased odds of cerebral infarction(OR=8.921,95% CI 2.16~30.32).Hcy was negatively correlated with Fol and VitB12.Conclusion Hyperhomocysteinemia is an independent risk factor in cerebral infarction.
出处
《中国实用神经疾病杂志》
2012年第8期19-20,共2页
Chinese Journal of Practical Nervous Diseases