摘要
目的研究偏钒酸钠对大鼠的协调能力和记忆力的影响。方法采用重复测量方差分析偏钒酸钠对大鼠协调能力和记忆力的影响。结果①染毒后,高、低剂量组大鼠出现腹泻或鼻炎症状,每组各有2只死亡,且实验后期体重较对照组为轻。②转棒实验,3组大鼠在棒上停留的时间表现为染毒后明显下降,染毒停止后持续上升的趋势,在30 d时点上转棒时间由低到高依次为高剂量组、对照组、低剂量照组,差异有统计学意义(P<0.05)。③水迷宫实验,3组大鼠到达终点的时间存在波动且差异无统计学意义(P>0.05)。错误次数的分析发现高、低剂量组大鼠均存在错误次数基线水平低,染毒后增加,停止染毒后减少的时间趋势,对照组大鼠的错误次数在各时点轻微波动;30 d时点上错误次数从从高到低依次为高剂量组、低剂量组、对照组,差异有统计学意义(P<0.05)。结论偏钒酸钠对大鼠的协调能力有损害作用,对大鼠的记忆力可能有损害作用。
Objective To explore the effect of vanadium on coordination and memory of rats. Method Rats＇ neurobehavioral outcomes of vanadium exposure were analyzed by MANOVA of repeated measuring data. Results （1）After poisoning, diarrhea or rhinitis occurred in high and low dose group, with 2 death in each group. The weight of rats in the late stage of experiment was lighter than control. （2） In Rotarod experiment, resident time in the bar presented that decreased significantly after exposure, and continued to rise after the cessation of expo- sure, The turning time was highest in low dose group, followed by control group and high dose group, with the differences statistically significant （P 〈 0. 05 ）. （3）In Maze experiment, the time that rats spent to the end with 3 groups fluctuated, with no statistical difference （P 〉 0. 05）. In the false numbers analysis, the number of errors exist in high and low dose group were in low baseline levels, presented the trend that increased after ex- posure, reduced after the cessation of exposure, The number of errors in control rats fluctuated lightly at each time point fluctuations. The number of errors in 30 d time point was highest inf high dose group, followed by low dose group and the control group, with the differences statistically significant （ P 〈 0. 05 ）. Conclusion Sodium metavanadate can decrease the coordination of rats, and may cause adverse effect on rats＇ memory.
出处
《预防医学情报杂志》
CAS
2012年第5期385-387,共3页
Journal of Preventive Medicine Information
关键词
偏钒酸钠
记忆力
协调能力
重复测量方差分析
水迷宫实验
转棒实验
sodium metavanadate
memory
coordination
MANOVA of repeated measuring
Maze experiment
Rotarod experiment
