摘要
目的 观察长效托宁与阿托品治疗急性有机磷农药中毒 (AOPP)的效果。方法 以长效托宁配合氯解磷定治疗 5 7例AOPP患者 ,并与阿托品配合氯解磷定治疗 2 2例AOPP患者进行比较。结果 长效托宁可使轻、中、重度AOPP患者中毒症状持续的时间缩短 ,M样症状时间分别为0 .2、0 .5、0 .6h ,对照组分别为 1.2、2 .3、3.7h ;中枢神经系统症状时间分别为 0 .7、4.7、12 .2h ,对照组分别为 13.8、17.3、19.3h ;用药量减少 ,分别为 2 .3、7.2、10 .2mg ,对照组分别为 11.0、2 6 .8、5 4.3mg ;治愈时间也缩短 ,分别为 1.1、1.9、2 .7d ,对照组分别为 1.8、2 .8、3.5d。两组比较 ,差异均有非常显著性(P <0 .0 1)。结论 长效托宁是一种比阿托品治疗效果好、不良反应少的抗胆碱能新药。
Objective To study the therapeutic efficacy and side reactions of long acting Tou Ning and atropine in the treatment of acute organophosphorus pesticide poisoning(AOPP).Methods The therapeutic effect of long acting Tuo ning+2PAM·Cl on 57 AOPP patients was compared to that of atropine+2PAM·Cl on 22 AOPP patients.Results There were significant differences between the 2 groups( P <0.01).Long acting Tuo Ning had better effects than atropine.The duration of muscarinic symptom in mild,moderate and severe AOPP patients were 0.2,0.5,0.6 h respectively vs .1.2,2.3,3.7 h;The duration of central nervous system symptom were 0.7,4.7,12.2 h respectively vs .13.8,17.3,19.3 h;The total drug doses used were 2.3,7.2,10.2 mg respectively vs . 11.0, 26.8,54.3 mg;The recovery time were 1.1,1.9,2.7 d respectively vs .1.8,2.8,3.5 d.There were Long acting Tuo Ning had less side effects too.Conclusion Long acting Tuo Ning may be a new anticholinergic drug which is better than atropine.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
2000年第2期85-87,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
有机磷农药中毒
长效托宁
阿托品
药物疗法
Organophosphorus pesticide poisoning
Long acting Tuo Ning
Atropine
