摘要
目的：对比研究心外科术后静脉芬太尼病人自控镇痛（ＰＣＡ）与传统间断肌肉注射镇痛（ＣＡＴ）的临床效果及安全性。 方法：将１８４例心外科术后病人分为 ＰＣＡ组和 ＣＡＴ组，其中 ＰＣＡ组 ９８例，ＣＡＴ组 ８６例。ＰＣＡ组用药为５０μｇ／ｍｌ的芬太尼，单次剂量２５μｇ，锁定时间 ６分，不给病人负荷剂量。拔除气管导管后病人感到疼痛时开始ＰＣＡ，直到拔管后７２小时。 ＣＡＴ组在病人需要镇痛时酌情肌肉注射吗啡１０ ｍｇ。分别在拔除气管导管后 ４、１２、２４、４８、７２、９６及 １２０小时，对病人进行随访并记录有关疼痛及副作用等各项指标。 结果：ＰＣＡ组疼痛总体满意度显著高于ＣＡＴ组，但恶心、呕吐、头晕发生率显著高于ＣＡＴ组。 结论：芬太尼ＰＣＡ用于心脏术后镇痛的疗效，优于常规间断肌肉注射吗啡。
Objective:To compare the clinical efficacy and safety of fentanyl per patient-controlled analgesia(PCA) intravenous- ly and intravenous morphine(CAT) after cardiac surgery. Methods:One hundred and eigty-four patients were enrolled into group PCA (98 cases) or group CAT(86 cases) af- ter obtained the consent form. The 50 μg/ml fentanyl was used in group PCA with 25 μg/ml per single dose at 6 minutes interval and no loading dose was administered. The PCA began after extubation and was applied for 72 hours. Morphine 10 mg was administered necessarily in the patients in group CAT whenever necessary. Close records were kept in 4, 12, 24, 48, 72, 96,and 120 hours after extubation in both groups. Result: Better satisfaction, and the percent age of nausea, vomiting and dizziness in group PCA were statistically higher. Conclusion:The efficacy of fentanyl PCA on the postoperative analgesia was much better than that of intravenous morphine.
出处
《中国循环杂志》
CSCD
北大核心
2000年第2期110-112,共3页
Chinese Circulation Journal
