摘要
目的:探讨survivin的亚细胞定位与临床病理特征的关系。方法:收集行乳腺癌改良根治术、保乳手术和(或)腋窝淋巴结清扫手术,病理诊断为浸润性乳腺癌的患者标本80例。采用免疫组织化学方法对样本survivin表达水平进行检测,分析乳腺癌中survivin的亚细胞定位与临床病理特征之间的关系。结果:乳腺癌组织中survivin的阳性率为76%,其中26%定位于细胞核,15%定位于细胞浆,两者染色均阳性为35%。亚细胞定位差异与淋巴结转移相关(P<0.05),与病例分级、ER表达、肿瘤大小无关(P>0.05)。结论:survivin在乳腺癌表达具有亚细胞定位差别,并且与淋巴结转移相关,提示该基因的不同定位在乳腺癌发生和转移过程中发挥着不同的作用。
Objective To explore the relationship between subcellular localization of survivin and clinical pathologic features of breast cancer patients. Methods Survivin expression was examined by immunohistochemistry in 80 primary breast cancer cases with clinical pathologic features. Results The expression of survivin was detected positive in 76% of the 80 breast cancer cases, among which 26% located in the nucleus,15% in cytoplasm, and 35% in both.Survivin expression in different subcellular localization was associated with lymph notes metastasis but independent of patients＂ pathologic grade, estrogen receptor expression, and tumor size. Conclusion Our data showed that survivin was expressed in different subcellular localization of breast cancer,and related to lymph nodes metastasis, which may be served as a Droanostic indicator of breast cancer
出处
《中国美容医学》
CAS
2012年第5期785-787,共3页
Chinese Journal of Aesthetic Medicine
基金
西京医院助推计划(XJZT10M06)
