摘要
目的 探讨重组人红细胞生成素 (r HuEPO)对维持性血液透析 (MHD)患者抗感染免疫功能的影响。方法 选取 17例MHD患者于静脉注射r HuEPO前和注射后取血清检测白介素 2 (IL 2 )、可溶性白介素 2受体 (sIL 2R)、白介素1(IL 1)、白介素 6 (IL 6 )、肿瘤坏死因子 ((TNF α)的含量和测血液中T淋巴细胞亚群的比例。另取 13例未注射r HuEPO治疗的MHD患者作为对照。结果 r HuEPO可提高MHD患者血清IL 2的含量、CD+ 4T细胞的比例、CD4 /CD8的比值 ;降低血清sIL 2R、IL 1和TNF α的含量。但对CD+ 8细胞比例、血清IL 6的含量没有明显的影响。结论 r HuEPO在改善贫血的同时可通过改变血清中细胞因子的含量、血中T细胞亚群的比例来增强机体的抗感染免疫功能。
AIM To investigate the effects of recombinant human erythropoietin(r HuEPO) on anti infection immunological functions of patients with maintainted hemodialysis(MHD). METHODS The serum levels of interleukin 2(IL 2), soluble interleukin 2 receptor(sIL 2),interleukin 1(IL 1),interleukin 6(IL 6),tumor necrosis factor α (TNF α) and the percentage of T cell subsets in blood of 17 patients with MHD treated with r HuEPO iv during routine hemodialysis were detected, and compared with the serum levels of cytokine and the percentage of T cell subsets of 13 patients with MHD not treated with r HuEPO iv. RESULTS r HuEPO coould enhance the serum levels of IL 2(P<0 05),the percentage of CD 4 positive cells(P<0 05) and CD 4/CD 8 ratio(P<0 05) in patients with MHD,and decrease the serum levels of sIL 2,IL 1 and TNF α. The serum levels of IL 6 and the percentage of CD + 8 positive cells were not significantly affected by r HuEPO. CONCLUSION In improving hypohemia of patiens with MHD, r HuEPO can promote anti infection immunological function by influencing serum levels of cytokine and T cell subsets ratio in blood.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2000年第2期218-220,共3页
Chinese Pharmacological Bulletin
关键词
R-HUEPO
维持性血液透析
细胞因子
r HuEPO
patients with maintainted hemodialysis
cytokine
T cell subsets
