摘要
以 1-取代苯乙基 - 4-哌啶醇和对硝基氟苯为原料 ,在 Na H/ DMF中制备得到了 1-取代苯乙基 - 4- ( 4 -硝基苯氧基 )哌啶 ( 1,2 )和分离得到了副产物 4 ,4′-二硝基苯醚 ( )和 N ,N -二甲基 - 4-硝基苯胺 ( ) ,并研究了副产物 , 的产生原因。以无水四氢呋喃代替 DMF,避免了副产物的生成 ,提高了
Substituted phenylethyl 4 (4 nitrophenyloxy) piperidines(Ⅲ 1,2 ) were prepared by reaction 1 substituted 4 hydroxypiperidine with sodium hydride and 1 fluoro 4 nitrobenzene in anhydrous DMF. Two impurities: bis ( p nitrophenyl) ether(Ⅴ) and N,N dimethyl p nitroaniline(Ⅵ) were isolated, and the causes of producing Ⅴ and Ⅵ were discussed. The yield of Ⅲ was raised and the impurities were eliminated by using anhydrous tetrahydrofuran as solvent instead of DMF.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2000年第2期81-83,共3页
Journal of China Pharmaceutical University
关键词
醚化反应
取代苯乙基
哌啶醇
芳氧烷胺化合物
Etherification
Impurity
DMF
Tetrahydrofuran
1-Substituted phenylethyl -4-hydroxypiperidines
