摘要
目的:观察加味茵陈蒿汤联合熊去氧胆酸治疗30例原发性胆汁性肝硬化临床分期为早中期患者的临床疗效。方法:60例患者随机分为对照组和治疗组各30例。两组均给予基础治疗,对照组患者同时口服熊去氧胆酸胶囊15～20mg.kg-1.d-1;治疗组患者在对照组基础上加服加味茵陈蒿汤,1剂/d,疗程均为24周。观察治疗前后两组患者的临床疗效、肝功能(γ-GT、ALP、ALT、AST、TBil)、免疫指标(IgM、IgG及IgA)的变化。结果:治疗结束时,治疗组26例(86.7%)患者得到完全反应,与对照组19例(63.3%)比较差异有显著性意义(P<0.05);两组患者治疗后肝功能(γ-GT、ALP、ALT、AST、TBil)均较治疗前明显下降(P<0.05),治疗组治疗后肝功能下降明显优于对照组(P<0.05或P<0.01);治疗后两组患者免疫指标IgM、IgG、IgA均较前有所下降,经比较差异无统计学意义(P>0.05)。结论:加味茵陈蒿汤联合熊去氧胆酸治疗原发性胆汁性肝硬化,较单用熊去氧胆酸疗效更好,并能明显改善患者的肝功能。
Objective： To observe the efficacy of ursodeoxycholic acid （UDCA） combined with modified Artemisiae Scopariae decoction for treating the patients with primary biliary cirrhosis （PBC） in II or III clinical stage. Methods： Sixty PBC patients were assigned randomly and equally to the control group and the treatment group, the control group was given basic treatment plus UDCA 15 -20mg · kg^-1 · d^-1 , besides the treatment of the control group, the patients in the treatment group took modified herbae artemisiae capillariae decoction, the treatment course was 24 wk. The clinical effect, biochemistry indicators （γ-GT, ALP, ALT, AST and TBil） and immunoglobulin levels （IgM, IgG and IgA） were compared before and after treatment. Results： After 24wk-treatment, in the treatment group 86. 7% （26/30 cases ） patients had CR, while in the control group, the ratio was 63.3% （ 19/30 cases）, showing a significantly better effect in the treatment group than in the control group （ P 〈 O. 05 ） ; In both control and treatment group, compared with before treatment, the levels of γ-GT, ALP , ALT, AST and TBil were decreased significantly （ P 〈 0.05 ） , but in control group, the level was still which were markedly higher than that those in the treatment group at the same （P 〈0. 05, P 〈0. 01 ） . In all patients , the levels of IgA, IgG and IgM decreased, but there was no significant difference （ P 〉 0. 05） . Conclusion ： Combined therapy of modified herbae artemisiae capillariae decoction and UDCA has better therapeutic effect than UDCA monotherapy to PBC, especially on improving liver function.
出处
《中西医结合肝病杂志》
CAS
2012年第2期89-91,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
