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ABCG5和ABCG8与胆囊结石关系的研究进展

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摘要 腺苷三磷酸结合盒转运体超家族G亚家族成员ABCG5和ABCG8是腺苷三磷酸结合盒转运体家族成员,在内质网产生后定位于细胞膜上发挥作用,具有从肠内细胞分泌胆固醇到肠腔内以及从肝脏分泌胆固醇到胆汁中的功能,促成了胆汁内胆固醇的过饱和,而胆固醇过饱和是形成胆囊结石的重要病理生理改变.本文就ABCG5、ABCG8的结构、功能等与胆囊结石形成原因作一综述.
作者 李炯 朱培庭
出处 《徐州医学院学报》 CAS 2012年第3期208-210,共3页 Acta Academiae Medicinae Xuzhou
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