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甲磺酸酚妥拉明对大鼠和家兔性行为的影响

Effects of phentolamine methylsulfonate on sexual behavior of male rats and rabbits
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摘要 应用阴茎勃起和交配行为及性激素测定实验观察了甲磺酸酚妥拉明 ( PM)对大鼠和家兔性行为的影响 .结果显示 ,大鼠 po PM1 0 - 2 0 mg· kg-1或兔 po PM4- 2 5mg·kg-1均能显著增加其阴茎勃起次数 ,延长阴茎勃起时间和提高动物阴茎勃起的阳性率 .起效时间均为 po后 1 h左右 .持续时间大鼠约 30 min,兔约 2 h左右 .另外 ,po PM对大鼠和兔的交配行为和血清性激素水平均没有明显的影响 .以上结果表明 ,PM是一种不促进性欲和非中枢作用的阴茎勃起促进剂 . The effect of phentolamine methylsulfonate(PM) was studied on the sexual behavior of male rats and rabbits. Oral administration of PM at doses ranging from 10 to 20 mg·kg -1 in male rats or from 4 to 25 mg·kg -1 in male rabbits induced significant increase in episodes of penile erection and percentage of the animal with penile erection, and prolonged duration of penile erection. The onset of action was about 1 h after oral administration of PM in male rats or rabbits. The duration of action was about 30 min in rats or about 2 h in rabbits. PM(4-25 mg·kg -1 , orally) did not affect copulatory behavior in male rats and rabbits. In addition, PM also did not signi ficantly affect testosterone, estradiol, and luteotropic hormone levels in serum of male rats, and testosterone and estradiol level in serum of male rabbits. These results suggest that PM act locally in the penile structure to cause penile erection and do not have aphrodisiac activity.
出处 《中国药理学与毒理学杂志》 CAS CSCD 北大核心 2000年第2期154-156,共3页 Chinese Journal of Pharmacology and Toxicology
关键词 甲磺酸酚妥拉明 阴茎勃起 性行为 性激素 phentolamine methylsulfonate penile erection sexual behavior sexual hormones
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