摘要
目的探讨细菌生物膜(BF)与慢性鼻-鼻窦炎的临床关系,分析细菌生物膜与难治性鼻窦炎的相关性。方法选择研究组24例慢性鼻-鼻窦炎(CRS)或伴有鼻息肉和对照组22例无CRS的鼻中隔偏曲患者,在扫描电镜及透视电镜下检测细菌生物膜是否存在,并对细菌生物膜的存在与部分临床指标进行相关分析。结果研究组24例患者中发现14例有细菌生物膜形成,对照组22例患者中发现2例有细菌生物膜形成,2组比较差异有统计学意义(P<0.01)。细菌生物膜阳性与细菌生物膜阴性的慢性鼻-鼻窦患者的症状VAS评分、鼻窦CT评分比较差异亦有统计学意义(P<0.05)。结论细菌生物膜在CRS患者中普遍存在,细菌生物膜与CRS的发病及其严重程度相关,是导致难治性鼻窦炎重要因素之一。
Objective To explore the relationship between bacterial biofilm and chronic rhinosinusitis and to analyze the correlation between bacterial biofilm and refractory rhinosinusitis.Methods 24 patients with chronic sinusitis（or associated with nasal polyps） and 22 control patients with deviations of nasal septum（without chronic sinusitis） were included in the study.The bacterial biofilm was observed using scanning electron microscopy and transmission electron microscopy in patients.The presence of bacterial biofilm and some clinical parameters were analyzed.Dichotomous data was analyzed by x2 or Fisher exact test,and continuous data was analyzed by T test.Results Fourteen out of the 24 patients in the experimental group were found the evidence of biofilm;In control group,only two out of 22 patients had biofilm,the difference was statistical significant（P0.01）.The preoperative VAS scores,preoperative CT scores of the CRS patients with biofilm were significantly different to those without biofilm（P0.05）.Conclusion Bacterial biofilm are prevalent in patients with CRS.The presence of bacterial biofilm in CRS patients is correlated with the severity of CRS and it is an important factor resulting into refractory rhinosinusitis.
出处
《宁夏医学杂志》
CAS
2012年第4期327-329,共3页
Ningxia Medical Journal
关键词
细菌生物膜
慢性鼻-鼻窦炎
难治性鼻窦炎
Bacterial biofilm
Chronic rhinosinusitis
Refractory rhinosinusitis
