摘要
Wnt信号通路是调节细胞发育和生长的一个关键途径,在正常情况下对胚胎发育和成人部分组织的形成和功能发挥起着重要作用。其异常激活则参与了人类多种肿瘤的发病过程,目前研究表明,Wnt通路中的多种因子与子宫肌瘤的发生发展有关,通过影响细胞凋亡、血管生成等发挥作用,并可与多种生长因子相互影响。但某些Wnt分子在子宫肌瘤中的表达尚存一定的争议。就Wnt信号通路与子宫肌瘤关系的研究进展进行简要综述。
Wnt signal pathway is a key way to regulate cell development and growth. In normal circumstances,it plays a significance role on the embryonic development and tissue formation. Its abnormal activation is involved in the pathogenesis of many human tumors. The present study show that a variety of molecules of Wnt signal pathway are closely related to the occurrence and development of uterine leiomyoma,which play roles by influencing apoptosis, angiogenesis, etc, and have interaction with many kinds of growth factors. However, some Wnt molecules expressed in the uterine leiomyoma is still disputed. This article is a brief review about recent advances in Wnt signal pathway and its relation to uterine leiomyoma.
出处
《国际妇产科学杂志》
CAS
2012年第2期137-140,共4页
Journal of International Obstetrics and Gynecology
基金
国家自然科学基金青年基金资助项目(30901919)
上海市教委重点学科资助项目(S30303)
关键词
蛋白质类
信号传导
子宫肿瘤
肌瘤
Proteins
Signal transduction
Uterine neoplasms
Myoma
