摘要
脂肪细胞分泌产物脂联素(adiponectin,APN)的发现是脂肪内分泌学研究领域的重大进展。它主要通过与相应受体结合,发挥相应的生物学效应,且其心血管保护作用目前已成为研究热点。动脉管壁上也存在其受体,在此基础上,将APN活性区域的脂联素球状域(globular domain of adiponectin,gAd)设计为新靶点,研究其对动脉管壁的保护作用及其相关机理,将为动脉粥样硬化疾病的防治提供新方案。
Adiponectin is a protein secreted exclusively by white adipose tissue and is abundantly present in human plasma.It has essential biological effects,and its protective effects on arteral wall have become a research hotspot.The globular domain of adiponectin is considered to be bioactive.It is a new target for studying the protective mechanism for vascular wall,which may have great significance in the preventive and therapeutic strategies of atherosclerosis.
出处
《生命的化学》
CAS
CSCD
2012年第2期127-130,共4页
Chemistry of Life
关键词
脂联素球状域
脂联素受体
保护机理
动脉管壁
globular adiponectin
adiponectin receptors
protective mechanism
vascular wall
