摘要
目的 探讨尘螨过敏与哮喘之间的关系。方法 测定不同年龄哮喘患儿和正常儿童的血清IgE水平以及尘螨皮试反应。结果 ①婴幼儿哮喘屋尘螨皮试阳性率较低 (34% ) ,在儿童哮喘则明显上升达 70 % (P <0 0 0 1) ;②各年龄组皮试阳性的哮喘患儿血清IgE水平均明显高于皮试阴性哮喘患儿 (P <0 0 0 1) ;③婴幼儿期血清IgE迅速升高 ,尤其婴幼儿哮喘上升幅度更加明显 ;进入儿童期后上升幅度明显放慢。结论 屋尘螨过敏是婴幼儿哮喘发展成儿童哮喘的重要因素之一 ;血清IgE升高与屋尘螨皮试表达有一定的关系 ,但它的表现明显早于屋尘螨皮试的表达 ;
Objective To search for the relationship between dust mite allergy and asthma.Methods The level of total serum IgE was detected by ELISA and the responses to dermatophagoides pteronyssinus(Dp) by skin prick test in 205 children with asthma and 187 healthy children.Results (1)The asthmatic children less than three year old had low positive rate of Dp skin test(34%),whereas the responses of Dp skin test significantly increased in children with asthma(positive 70%).(2)The level of serum IgE of asthmatic children with positive skin test had much higher than asthmatic children with negative skin test.(3)The level of serum IgE in asthmatic children less than three year old was significantly higher than the same age healthy children,though there were not different positive skin test rate between both.Conclusion Allergy to Dp might be one of the important factors which make early children asthma develop into children asthma and associated with increase of the level of serum IgE,but the increase of serum IgE was earlier than skin express of allergy to Dp.So early and dynamic detecting of serum IgE is helpful for evaluating the prognosis of early children asthma.
出处
《中国实用儿科杂志》
CSCD
北大核心
2000年第1期39-40,共2页
Chinese Journal of Practical Pediatrics
关键词
哮喘
免疫球蛋白E
儿童
尘螨过敏
Asthma Immunoglobulin E Dermatophagoides pteronyssinus
