摘要
目的:探讨一氧化氮(NO)和血管紧张素Ⅱ(AngⅡ)与原发性高血压(EH)的关系。方法:分别选择EH合并左室肥厚(LVH)患者(EH+LVH组)、EH无LVH患者(EH组)及正常人(正常对照组)各30例,检测NO、AngⅡ水平,并进行组间比较分析。结果:(1)EH+LVH组NO水平明显低于EH组、正常对照组[(37.24±11.27)μmol/L比(51.79±20.04)μmol/L比(80.25±20.58)μmol/L],且EH组NO水平明显低于正常对照组(P均<0.01);EH+LVH组AngⅡ水平明显高于EH组、正常对照组[(198.37±93.54)ng/L比(139.87±56.39)ng/L比(57.34±18.85)ng/L],且EH组AngⅡ水平明显高于正常对照组(P<0.05～<0.01);(2)直线相关分析显示收缩压、舒张压与NO呈负相关(r=-0.448、P=0.000;r=-0.249,P=0.018),与AngⅡ呈正相关(r=0.491,P=0.000;r=0.265,P=0.012),NO与AngⅡ呈负相关(r=-0.555,P=0.000)。结论:一氧化氮、血管紧张素Ⅱ参与了原发性高血压发病的病理生理过程。
Objective： To investigate relationship among nitric oxide（NO）,angiotensin Ⅱ（AngⅡ） and essential hypertension（EH）.Methods：A total of 30 EH patients complicated left ventricular hypertrophy（LVH,EH＋LVH group）,30 EH patients without LVH（EH group） and 30 normal subjects（normal control group） were selected.Levels of NO and Ang Ⅱ were measured,compared and analyzed among the three groups.Results：（1） NO level in EH＋LVH group was significantly lower than those of EH group and normal control group [（37.24±11.27） μmol/L vs.（51.79±20.04） μmol/L vs.（80.25±20.58） μmol/L],and that of EH group was significantly lower than that of normal control group（P0.01）;AngⅡ level in EH＋LVH group was significantly higher than those of EH group and normal control group [（198.37±93.54） ng/L vs.（139.87±56.39） ng/L vs.（57.34±18.85） ng/L],and that of EH group was significantly higher than that of normal control group（P0.05~0.01）;（2） Linear correlation analysis showed that systolic blood pressure and diastolic blood pressure were negatively correlated with NO（r=-0.448、P=0.000;r=-0.249,P=0.018）,positively correlated with AngⅡ（r=0.491,P=0.000;r=0.265,P=0.012）,and NO was negatively correlated with AngⅡ（r=-0.555,P=0.000）.Conclusion： Nitric oxide and angiotensin Ⅱ are involved in pathogenic process of essential hypertension.
出处
《心血管康复医学杂志》
CAS
2012年第2期147-149,共3页
Chinese Journal of Cardiovascular Rehabilitation Medicine
