摘要
目的:利用Meta分析方法评价苯肾上腺素和麻黄素对剖宫产新生儿血气的影响。方法:查阅中国期刊全文数据库(CNKI)、PubMed、万方数据库、维普中文科技期刊全文数据库(VIP)、中国生物医学文献数据库(CBM)2000-2011年3月公开发表的随机对照临床试验文献,按照纳入与排除标准选择文献、评价质量和提取数据,采用RevMan4.2软件进行Meta分析。结果:纳入10篇文献,2组新生儿脐动脉血的pH值[WMD=0.05,95%CI(0.04,0.06),P<0.00001]和氧分压(PO2)[WMD=0.52,95%CI(0.08,0.96),P=0.02]以及二氧化碳分压(PCO2)[WMD=-4.35,95%CI(-5.00,-3.69),P<0.00001]差异均有统计学意义;2组新生儿脐动脉血的剩余碱(BE)[WMD=1.38,95%C(I-0.15,2.92),P=0.08]差异无统计学意义。结论:苯肾上腺素有利于增加胎儿氧供,降低缺氧性酸中毒,值得临床推广应用。
OBJECTIVE： To evaluate the effects of phenylephrine and ephedrine on blood gas of caesarean delivery newborns by Meta-analysis. METHODS： We searched literatures published during 2000-Mar. 2011 from CNKI, PubMed, Wanfang database, VIP and CBM. The methodological qualities of the included studies were evaluated and the data was extracted according to inclusion and exclusion criteria. Meta-analyses were performed using RevMan 4.2 software. RESULTS： A total of 10 studies were included. The results of Meta-analyses indicated that： the pH value [WMD=0.05,95%CI（0.04,0.06）,P0.000 01], PO2 [WMD=0.52,95%CI（0.08,0.96）,P=0.02] and PCO2 [WMD=-4.35,95%CI（-5.00,-3.69）,P0.000 01] in arteria umbillicalis of the two groups had significant difference. However, there was no significant difference in BE value [WMD=1.38,95%CI（-0.15,2.92）,P=0.08] between the two groups. CONCLUSION： Phenylephrine contributes to the oxygen supply and decreases the incidence of acidosis in infants. It is worthy of being popularized in the clinic.
出处
《中国药房》
CAS
CSCD
2012年第18期1690-1692,共3页
China Pharmacy
