摘要
目的 探讨子宫内膜异位症病人体内免疫学改变。方法 对１８例正常生育期的妇女及３４例各期内膜异位症的患者分别检测其血清及腹腔液中抗子宫内膜抗体、ＩＬ４、ＩＦＮγ的水平。结果 血清中内异症组与对照组比较抗子宫内膜抗体阳性率有显著性差异（Ｐ＜０．００５）；ＩＬ４水平在腹腔液中内异症各期与对照组比较及内异症Ⅰ期与Ⅱ期以上组间比较均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０５，Ｐ＜０．０５）。血清中ＩＬ４水平在内异症Ⅱ期以上组与对照组相比有显著性差异（Ｐ＜０．０５）。ＩＦＮγ在腹腔液中内异症各期组与对照组比较均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。结论 子宫内膜异位症腹腔液中ＩＬ４、ＩＦＮγ变化较血清中明显。随着内异症期别的增加，腹腔液ＩＬ４、ＩＦＮγ均有上升的趋势，尤以ＩＬ４升高更为明显。子宫内膜异位症血清中抗子宫内膜抗体的变化较腹腔液中明显。
Purpose To study the immune pathogenesis of endometriosis. Methods Antiendometrial antibodies,IL?4 and IFN?γ in sera and peritoneal fluids were measured by ELISA in 18 healthy fertile women and 34 patients with endometriosis. Results The positive rate of antiendometrial antibodies in sera from patients with endometriosis was significantly higher than that of the fertile women without endometriosis ( P <0.005).IL?4 levels of peritoneal fluids from endometriosis of different stages elevated significantly as compared to the normal controls ( P<0.05,P<0.05 ).IL?4 levels of peritoneal fluids from endometriosis of stage II to IV groups apparently were higher as compared to endometriosis of stage I group ( P< 0.05).There were significant differences of IL?4 levels in sera between endometriosis of stage II to IV groups and the normal controls ( P <0.05) .IFN?γ levels of peritoneal fluids from endometriosis of different stages increased significantly as compared to the normal controls ( P<0.05,P<0.01 ). Conclusions In endometriosis the changes of IL?4 and IFN?γ in peritoneal fluids were predominant as compared with those in sera.IL?4 and IFN?γ concentrations in peritoneal fluids elevated as endometriosis stage rised,and the elevation of IL?4 concentration was more ob vious .In endometriosis the changes of antiendometrial antibodies in sera were more obvious than those in peritoneal fluids.
出处
《上海医科大学学报》
CSCD
2000年第1期45-47,共3页
Journal of Fudan University(Medical Science)
