摘要
目的探讨透明质酸钠关节腔注射对骨性关节炎的临床疗效、安全耐受性及对血清与滑膜液中IL-1、IL-6水平的影响。方法取34例有膝关节腔积液的骨性关节炎患者随机分成两组,分别给予关节腔注射透明质酸钠与非甾体药治疗,观察治疗前后关节休息痛、活动痛、压痛、肿胀与关节功能改善程度,并分析其安全耐受性;同时测定治疗前后血清与滑膜液中IL-1、IL-6水平变化。结果治疗组关节各种症状均有改善,尤以活动痛与肿胀改善显著,优于对照组。治疗后治疗组血清与滑膜液中IL-1、IL-6水平均低于治疗前,有显著差异。治疗组安全耐受性较好。结论骨性关节炎发病机制与关节滑膜细胞分泌过多的IL-1、IL-6并释放入血有关。透明质酸钠关节腔注射能有效地缓解关节疼痛、肿胀与改善关节功能,安全耐受性较好,并可降低血清与滑膜液中IL-1、IL-6水平。
ObjectiveTo explore clinical effects and safety of intraarticular injection with natrii hyaluronic acid on osteoarthritis and its influences on titers of IL 1,IL 6 in sera and synovial fluid.Methods34 osteoarthritis patients with knee joint hydrathrosis were randomizedly divided into treatment group and control group,which received intraarticular injection of natrii hyaluronic acid and convertional therapy respectively.And then articular resting pain,active pain,tenderness,swelling,function and titers of IL 1,IL 6 in sera and synovial fluid before and after therapy were recorded.ResultsTreatment group had good efficacy in relieving various symptoms,especially in active pain and swelling,was superior to control group,and possessed fine safety as well.The titers of IL 1,IL 6 in sera and synovial fluid after therapy in treatment group were lower than those before therapy.ConclusionIntraarticular injection with natrii hyaluronic acid possesses good efficacy in relieving articular pain,swelling and function,has fine safety and can downregulate titers of IL 1,IL 6 in sera and synovial fluid in osteoarthritis patients. [
出处
《免疫学杂志》
CAS
CSCD
北大核心
2000年第1期55-57,共3页
Immunological Journal
关键词
骨性关节炎
透明质酸钠
关节腔注射
osteoarthritis
natrii hyaluronic acid
intraarticular injection
clinical efficacy
IL 1
IL 6
