摘要
本研究应用酶联免疫(EIA)及核酸斑点杂交法对我省部分地区227例乙型肝炎患者检测了HDAg、抗-HD及HDVRNA。结果4例抗-HD阳性,1例HDAg与HDVRNA均为阳性,HDVM检出率为2.2％(5/227)。证实了丁型肝炎在福建省的存在,但感染率低,呈散在分布。各临床型乙肝患者HDVM检出率分别为:急性肝炎1.5％(1/67);慢性肝炎3％(4/135);HBsAg无症状携带者0(0/25)。慢性肝炎患者HDVM检出率明显高于HBsAg携带者,提示HDV感染与HBsAg阳性的慢性肝病密切相关。并发现本研究5例HDV感染者临床表现均为重叠感染,绝大多数患者HBV复制指标受到抑制。
By using EIA and Nucleic Acid Spot Hybridization, we examined HDAg, Anti-HD, and HDV-RNA among 227 patients with hepatitis B in some areas of Fujian province. It was found that four cases were anti-HD positive and one case was HDAg and HDV-RNA positive, with HDVM positive rate of 2. 2% (5/227) . The results confirm that hepatitis delta exixts in Fujian province but with a low infectious rate and dispersive distribution. In clinics, HDVM positive rates of acute hepatitis, chronic hepatitis and asymptomatic HBsAg carriers respectively were 1. 5% (1/67), 3% (4/135) and 0% (0/25) . The HDVM positive rate of patients with chronic hepatitis is higher than that of HBsAg carriers. It shows that HDV infection is closely related to chronic hepatopathy with HBsAg positive. In addition, it was found that the clinical feature of five patients infected by HDV was superinfection and the HBV replication of most patients were inhibited.
出处
《中国人兽共患病杂志》
CSCD
北大核心
1990年第4期8-10,共3页
Chinese Journal of Zoonoses
