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拉坦前列素对高眼压的治疗效果及安全性观察 被引量:3

THE EFFICACY AND SAFETY OF LATANOPROST FOR THE TREATMENT OF OCULAR HYPERTENSION
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摘要 目的探讨拉坦前列素治疗不同程度高眼压的临床疗效及安全性。方法选取42例(70只眼)原发性开角型青光眼病人,根据眼压≥3.99kPa和<3.99kPa分为两组,均给予拉坦前列素治疗,每天1次,共随访观察8周。观察指标包括常规的视力、眼压、眼部症状及体征,并询问病人用药后反应。结果用药8周后两组眼压比较,差异有显著性(t=2.504,P<0.05)。各组内用药前后各时间点眼压比较,差异有显著性(F=11.469、16.048,P<0.001)。两组治疗后眼压下降幅度比较,差异有显著意义(t=6.410,P<0.001)。42例病人中,眼压≥3.99kPa组2例出现结膜充血,继续治疗充血消失,无不适;1例出现角膜点状混浊,停止治疗。眼压<3.99kPa组1例出现结膜充血,继续治疗充血消失,无不适;1例出现虹膜色素沉着,继续治疗无不适。结论拉坦前列素对眼压≥3.99kPa和<3.99kPa的原发性开角型青光眼病人均能有效降低眼压,眼压≥3.99kPa组病人眼压下降幅度大于眼压<3.99kPa组,且不良反应少,安全性高。 Objective To assess the safety and efficacy of latanoprost in treating different-degree ocular hypertension. Methods Forty-two patients(70 eyes) with open-angle glaucoma were divided into two groups,based on intraocular pressure(IOP) of ≥3.99 kPa or 3.99 kPa.The patients were treated with latanoprost,once a day for eight weeks.The vision,intraocular pressure,eye symptoms and signs were observed and drug reactions inquired. Results After eight weeks of medication,the difference of IOP between the two groups was significant(t=2.504,P〈0.05).In each group,the difference of IOP at each time point between before and after medication was significant(F=11.469,16.048;P〈0.001).After medication,the difference of the range of descending IOP between the two groups was significant(t=6.410,P〈0.001).Among the 42 patients,two of those in IOP of ≥3.99 kPa group presented conjunctival congestion,which disappeared as the treatment continued,with no complaints;one presented spotty corneal opacity,medication was discontinued.In IOP of 3.99 kPa group,one presented conjunctival congestion and disappeared later while the medication continued.Iris pigmentation appeared in one patient. Conclusion Latanoprost is effective and safe in reducing IOP in primary open-angle glaucoma of patients with an intraocular pressure of ≥3.99 kPa or 3.99 kPa,the reduction of pressure in the ≥3.99 kPa group was greater than that of 3.99 kPa.
出处 《青岛大学医学院学报》 CAS 2012年第2期173-174,176,共3页 Acta Academiae Medicinae Qingdao Universitatis
关键词 拉坦前列素 高眼压 治疗结果 latanoprost ocular hypertension treatment outcome
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