摘要
目的分析大分割放疗联合PD方案同步化疗治疗局部晚期非小细胞肺癌的临床疗效及毒副作用。方法资料完整的92例局部晚期非小细胞肺癌患者随机分为对照组和大分割组,大分割组接受X射线照射(DT:62.5Gy/25F/5W)并同步给予PD方案化疗4周期,对照组接受常规X射线照射(DT:66～70Gy/33～35F/7W)并同步给予PD方案化疗4周期,治疗结束后评价疗效和不良反应。结果近期有效率大分割组为86.96%(40/46),高于对照组的78.26%(36/46),P>0.05,差异无统计学意义;常见毒副作用主要为骨髓抑制、放射性肺炎、消化道反应及放射性食管炎,大多为Ⅰ～Ⅱ级,未见Ⅳ级不良反应,两组间比较P>0.05,差异无统计学意义。结论大分割放疗联合PD方案同步化疗是治疗局部晚期非小细胞肺癌的有效手段,能缩短放疗时间,且不加重毒副作用。
Objective To observe the efficiency and toxicity of treatment of locally advanced non-small cell lung cancer by hypofractionated conformal radiotherapy concurrent with PD regimen chemotherapy.Methods Ninty two patients with locally advanced non-small cell lung cancer were randomly divided into two groups：46 cases in hypofractionated conformal radiotherapy group（DT：62.5Gy/25F/5W）and 46 cases in control group（DT：66-70Gy/33-35F/7W）,all receive 4 circles of treatment of PD regimen chemotherapy in both group concurrently.Efficiency and toxicity were evaluated after the treatment.Results The short-term effective rate in hypofractionated conformal radiotherapy group was 8.70% more than control group with total response rate 86.96%（40/46）.No significant difference was shown in statistics（P 0.05）.The major adverse effects were hematological toxicity,radiation pneumonitis,vomiting and radiation esophagitis in grade Ⅰ-Ⅱ,which took a favorable turn after heteropathy.The adverse effects in grade Ⅳ were not turn up.There was no significant difference between two groups（P 0.05）.Conclusion Hypofractionated conformal radiotherapy concurrent with PD regimen chemotherapy shows good efficacy and tolerable toxicity in treatment of patients with non-small cell lung cancer.
出处
《中国当代医药》
2012年第11期39-40,42,共3页
China Modern Medicine
关键词
非小细胞肺癌
放疗
多西他赛
临床疗效
Non-small cell lung cancer
Radiotherapy
Taxotere
Efficiency
