摘要
纳米科学是21世纪重点支柱领域之一。目前纳米粒子的生物安全性体外实验已取得了一些研究成果,但其体内安全性评价,由于受到限制而进展缓慢。而斑马鱼是纳米粒子体内生物安全性评价的最佳模式生物。本文就目前国内外开展的纳米粒子体内毒理学的研究方法和成果以及以斑马鱼作为模式生物研究纳米粒子体内毒性机制的优势进行了综述。
Science in nanometer scale,one of the most important research fields in 21 century.In present,achievements that have been made in nanotoxicity are basically based on in vitro systems.However,in vivo study developed tardily.Zebrafish,a kind of mode organism,which has more advantages than others in toxicity assessment,will be used more and more wildly in this field.This review summarized some investigative methods,results of in vivo nanostructures toxicology and the advantages of the mode organism--zebrafish to provide some help for its development and the methods being systematism.
出处
《中国药理学与毒理学杂志》
CAS
CSCD
北大核心
2012年第2期251-254,共4页
Chinese Journal of Pharmacology and Toxicology
关键词
纳米粒子
毒理学
斑马鱼
nanoparticles
toxicology
zebrafish
