摘要
目的 为了解肠癌患者外周血(PB)中粘附分子(CD_(44))水平的临床意义。 方法 用流式细胞术检测了105例肠癌患者术前PB中CD_(44)水平和免疫细胞亚群,进行临床病理分析并与100例正常人PB中CD_(44)％作统计学处理比较。 结果 正常人PB中CD_(44)％为46.14±13.41,CD_(44)％与年龄、性别比较无统计学意义.直肠癌患者PB中CD_44％(54.17±16.62)与正常人比较差异有非常显著性(P<0.01),外生型癌患者PB中CD_(44)％(55.10±18.52)与正常人比较差异有非常显著性(P<0.01),肿瘤>4cm～8cm(53.48±16.97)和>9cm(63.67±12.99)患者PB中CD_(44)％与正常人比较差异有非常显著性(P<0.01),中分化腺癌患者PB中CD_(44)％(51.83±18.15)与正常人比较差异有显著性(P<0.05),低分化腺癌患者PB中CD_(44)％(58.31±14.66)与正常人比较差异有非常显著性(P<0.01),有淋巴结转移者PB中CD_(44)％(53±19.51)与正常人比较差异有显著性(P<0.05),DukesA+B期患者PB中CD_(44)％(51.09±15.83)与正常人比较差异有显著性(P<0.05),D期患者PB中CD_(44)％(63.93±13.9)与正常人比较差异有非常显著性(P<0.01),女性肠癌患者PB中CD_(44)％(55.07±17.17)与正常女性比较差异有非常显著性(P<0.01),<59岁肠癌患者PB中CD_(44)％(54.76±16.39)
AIM To understand the clinical significance of cell adhesive molecules (CD44) in the peripheral blood (PB) of patients with colorectal cancer.METHODS The level of CD44 in PB of 105 patients with colorectal cancer was examined by flow cytometry and the results were clinicopathologically and statistically analyzed.RESULTS The mean of the CD44% in PB of the normal individuals was 46.14±13.41 and there were no statistical differences for their age and sex. The significant difference (P<0.01) was present between the patients with the rectal cancer CD44% (54.17±16.62) and normal individuals. There was significant difference (P<0.01) between the patients with expophytic type colorectal cancer CD44% (55.10±18.52) and normal individuals, between the patients with >4 cm-8 cm (53.48±16.97) and >9 cm (63.67±12.99) mass CD44% and normal individuals (P<0.01). between the patients with maderatdy differentiated adenocarcinoma CD44% (51.83± 18.15) and normal individuals (P<0.05), between the patients with lowly differentiated adenocarcinoma CD44% (58.31±14.66) and normal individuals (P<0.01), between the patients with the metastatic lymph node CD44% (53±19.51) and normal individuals (P<0.05), between the patients with Dukes A+B stage CD44% (51.09 ±15.83 ) and normal individuals (P<0.05), between the patients with Dukes D stage CD44% (63.93±13.92) and normal individuals (P<0.01), between the female patients CD44% (55.07±17.17) and normal female individuals (P<0.01) and between the patients with age <59 CD44% (54.76±16.39) and normal individuals (P<0.01).CONCLUSION The increased level of CD44 in PB of patients with colorectal cancer may be closely linked with site of tumor growth, type of tumor mass, size of tumor mass, degree of tumor differentiation, metastatic lymph node, clinical stage, sex, age of patients. Examining level of CD44% in the periphery blood of patients with colorectal cancer by flow cytometry can suggest prognosis of patients.
出处
《世界华人消化杂志》
CAS
2000年第4期432-435,共4页
World Chinese Journal of Digestology
基金
浙江省医药卫生科研基金
No.98001
关键词
大肠癌
细胞免疫
流式细胞术
病理学
淋巴转移
intestinal neoplasms
immunity, cellular
flow cytometry
pathology
adenocarcinoma
rectal neoplasms
lymphatic metastasis
research
