摘要
目的探讨脾血管内皮细胞瘤的临床病理学特征、诊断及鉴别诊断要点。方法报道3例罕见的脾血管内皮细胞瘤,结合文献对其临床表现、组织形态、免疫组化及治疗预后进行分析。结果男性1例,女性2例,年龄27～51岁,平均年龄35岁。患者因影像学检查示脾占位就诊。大体观察均为局限单个边界清楚肿物。镜下均可见大量血管内皮泡沫样细胞、血管增生及扩张。免疫组化:CD31和CD34(+),CD68局部(+),SMA(■),CK(-)。结论脾上皮样血管内皮细胞瘤是一种罕见的肿瘤,确诊需依靠病理检查及免疫组化,具有细胞内血管腔的上皮样瘤细胞并呈血管内皮标记物阳性是该病病理诊断的两个重要特征。需同脾其他肿瘤鉴别。
Objective To investigate the clinicopathologic features,diagnosis and differential diagnosis of splenic hemangioendothelioma.Methods Three cases of a rare splenic tumor of vascular endothelial cells,combined with literature on their clinical presentation,morphology,immunohistochemistry and prognosis were analyzed.Results The patients were one male and 2 females,aged 27-51 years（mean 35）,and saw doctors for a splenic mass revealed by imaging.Gross examination showed a single mass with a clear boundary.Microscopically,the tumor was composed of foam-like endothelial cells with vascular proliferation and dilation.Immunohistochemical staining showed that tumor cells were positive for CD31 and CD34,focally positive for CD68 and SMA,but negative for CK.Conclusions Splenic hemangioendotheioma is a rare tumor and its correct diagnosis relies on pathological examination and immunohistochemical staining,which show the epithelioid cells with lumen-like structure and positive reaction to endothelial markers.It is also needed to differentiate from other splenic tumors.
出处
《诊断病理学杂志》
CSCD
北大核心
2012年第2期115-117,共3页
Chinese Journal of Diagnostic Pathology
关键词
脾
上皮样血管内皮细胞瘤
梭形血管内皮细胞瘤
病理诊断
Spleen
Epithelioid hemangioendothelioma
Spindle cell hemangioendothelioma
Pathological diagnosis
