摘要
以天然的咖啡酸、甘草次酸和齐墩果酸为原料,采用侧基保护、还原、酰化与去保护等步骤,将咖啡酰基及氢化咖啡酰基引入到甘草次酸和齐墩果酸的3-位羟基上,以较高收率合成了4个新的咖啡酸及氢化咖啡酸五环三萜酯类化合物,通过IR,1H NMR,HRMS等方法确定了化合物的结构.
Four new caffeyl triterpenic esters were synthesized from natural caffeic acid,glycyrrhetinic acid and oleanolic acid.The structures of all products were characterized by IR,1 H NMR and HRMS techniques.The activities of the compounds to protect liver was tested and compound 9c showed good hepatic protective effect.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2012年第4期760-764,共5页
Chinese Journal of Organic Chemistry
