摘要
采用串联氮杂Wittig反应,合成了5种未见文献报道的2-芳氧基-噻吩并[2,3-d]嘧啶-4(3 H)-酮衍生物。首先由膦亚胺与芳基异氰酸酯反应得到碳二亚胺,再与取代酚在碳酸钾的催化下反应得到目标化合物,收率为62%～85%,并采用元素分析、IR、MS、1 HNMR等手段对目标化合物的结构进行了确证。
Five kinds of 2-aryloxy-thienopyrimidin-4（3H）-one derivatives were synthesized by aza-Wittig reaction.Firstly carbodiimides were synthesized by iminophosphorane and aromatic isocyanates,then,the object compounds were synthesized by carbodiimides and substituted phenol in the presence of catalyst solid K2CO3 with yield of 62%~85%.And their structures were characterized by elemental analysis,IR,MS,1HNMR.
出处
《化学与生物工程》
CAS
2012年第4期32-33,53,共3页
Chemistry & Bioengineering
基金
湖北省科技厅自然科学基金资助项目(2011CDB08301)
湖北省教育厅科研项目(B20102103)
