摘要
AIM:To evaluate the noninvasive parameters and hepatic fibrosis scores in obese children with nonalcoholic fatty liver disease(NAFLD).METHODS:A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic staging of hepatic fibrosis:mild(stage 0-1)vs significant fibrosis(stage 2-4).Clinical and laboratory parameters were evaluated in each patient.The aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST/platelet ratio index(APRI),PGA index,Forns index,FIB-4,NAFLD fibrosis score,and pediatric NAFLD fibrosis index(PNFI)were calculated.RESULTS:No clinical or biochemical parameter exhibited a significant difference between patients with mild and significant fibrosis.Among noninvasive hepatic fibrosis scores,only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis(APRI:0.67±0.54 vs 0.78±0.38,P=0.032 and FIB4:0.24±0.12 vs 0.31±0.21,P=0.010).The area under the receiving operating characteristic curve of FIB4 was 0.81,followed by Forns index(0.73),APRI(0.70),NAFLD fibrosis score(0.58),AST/ALT ratio(0.53),PGA score(0.45),and PNFI(0.41).CONCLUSION:APRI and FIB4 might be useful noninvasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD.
AIM： To evaluate the noninvasive parameters and he- patic fibrosis scores in obese children with nonalcoholic fatty liver disease （NAFLD）. METHODS： A total of 77 children diagnosed with NAFLD via liver biopsy were included and divided into 2 subgroups according to the histopathologic stag- ing of hepatic fibrosis： mild （stage 0-1） vs significant fibrosis （stage 2-4）. Clinical and laboratory parameters were evaluated in each patient. The aspartate amino- transferase （AST）/alanine aminotransferase （ALT） ratio, AST/platelet ratio index （APRI）, PGA index, Forns index, FIB-4, NAFLD fibrosis score, and pediatric NAFLD fibro- sis index （PNFI） were calculated.RESULTS： No clinical or biochemical parameter exhib-ited a significant difference between patients with mild and significant fibrosis. Among noninvasive hepatic fi- brosis scores, only APRI and FIB4 revealed a significant difference between patients with mild and significant fibrosis （APRI： 0.67 ± 0.54 vs 0.78 ± 0.38, P = 0.032 and FIB4：0.24 ± 0.12 vs 0.31 ± 0.21, P = 0.010）. The area under the receiving operating characteristic curve of FIB4 was 0.81, followed by Forns index （0.73）, APRI （0.70）, NAFLD fibrosis score （0.58）, AST/ALT ratio （0.53）, PGA score （0.45）, and PNFI （0.41）. CONCLUSION： APRI and FIB4 might be useful non- invasive hepatic fibrosis scores for predicting hepatic fibrosis in children with NAFLD.
