摘要
目的 探讨高剂量化疗用外周血干细胞支持提高小细胞肺癌的疗效、可行性、安全性。方法 小细胞肺癌首先采用常规化疗后取得病灶缩小者,动员外周血干细胞后用血细胞分离仪采取外周血干细胞后,再用高剂量化疗CVpP方案,化疗后24～48小时干细胞回输。观察白细胞变化,当白细胞<1.5×109/L时进入层流室保护,直到白细胞>1.5×109/L时出层流室,转普通病房。3周后胸片复查,达CR或PR者。有手术指征者予以切除,其中1例高剂量衡量后达PR,予手术切除,术后标本仅残留少量癌细胞,无手术指征者再进行放疗。结果 近期疗效有效率达100%(CR27%,PR73%),白细胞在第10～12天恢复正常,血小板在第13～14天恢复正常。主要不良反应为度骨髓抑制,仅1例有皮肤感染,未发生与治疗有关的死亡。结论 外周血干细胞支持合并高剂量化疗在肺癌治疗中有效、安全、可行。
Objective To evaluate feasibility and efficacy of mega dose chemotherapy with peripheral blood stem cell support for SCLC.Methods SCLC patients obtained shrink of lesion after conventional chemotherapy (CT) and PBSC were harvested with hematocrit machine in mobilization.Then mega dose CT of CVpP was given and stem cells were reinfused after 24～48 h of CT.The patients entered the laminarflow room when the leucocytes<1.5×10 9/L until more than 1.5×10 9/L.Chest film was retaken in 3 weeks and patients were sent to surgery when reached complete or partial response.One case underwent lobectomy and little residual cancer cell was found in specimen resected.Otherwise radiotherapy was taken in inoperable patients.Results The response rate was 100% (CR 27%,PR 73%).Hematologic recovery was rapid.WBC count was >1.0×10 9/L in 10～12 day,Plt were ≥30×10 9/L in 13～14 day.Main side effect was myelosuppression Ⅳ,one case had dermatitis,no death associated with PBSCS.Conclusion Mega dose chemotherapy with peripheral blood stem cell support for lung cancer was effective,secure,feasible.
出处
《实用肿瘤杂志》
CAS
北大核心
2000年第1期19-22,共4页
Journal of Practical Oncology
关键词
肺肿瘤
药物疗法
小细胞肺癌
外周血干细胞
lung neoplasms/drug therapy
lung neoplasms/therapy
hematopoietic stem cells
bone marrow transplantation
