摘要
目的:研究泽泻滴丸的最佳成型工艺。方法:以滴丸的外观质量、溶散时限与丸重差异为评价指标,采用正交试验法对基质配比、含药量、药液温度和滴距等因素进行优选。结果:泽泻滴丸的最佳成型工艺条件是以液体石蜡为冷凝剂,含药量30%,基质比例PEG4000-PEG6000 1∶3,药液温度(85±1)℃,滴距2 cm,冷凝液温度(6±0.2)℃,冷却距离70 cm,滴速40 d·min-1,滴管口内外径分别为1.64,2.22 mm。结论:优选的泽泻滴丸成型工艺简明可行,滴丸成型性好,适宜工业化生产。
Objective：To study on optimum forming technology of Zexie dropping pill.Method： With appearance quality,dissolved time,weight difference of dropping pill,orthogonal test was used to optimize ratio of matrix,the content of drug,temperature of liquid,dropping distance and other factors.Result： Optimum forming technology conditions of Zexie dropping pill were as follows： liquid paraffin was refrigerant,the content of drug was 30%,PEG 4000-PEG 6000（1∶3） was optimal matrix ratio,liquid temperature was（85±1） ℃,dropping distance was 2 cm,temperature of refrigerant was（6±0.2） ℃,freeze-pillar height was 70 cm,dropping velocity was 40 drops per minute,internal and external diameter of burette was 1.64 mm and 2.22 mm.Conclusion： Optimized forming technology of Zexie dropping pill was simple and feasible,and suitable for industrial production.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第8期28-30,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
福建社发处重大专项专题项目(2009YZ0001-1-5)
关键词
泽泻滴丸
成型工艺
聚乙二醇
Zexie dropping pill
forming technique
Polyethylene glycol
