摘要
目的:探讨涎腺黏液表皮样癌多药耐药基因P-gp、GST-π和TopoⅡ的表达情况及意义。方法:应用免疫组织化学技术(SP法)检测37例涎腺黏液表皮样癌及12例正常涎腺组织中P-gp、GST-π和TopoⅡ的表达。结果:P-gp、GST-π和TopoⅡ在涎腺黏液表皮样癌及正常涎腺组织中均有不同程度表达。涎腺黏液表皮样癌组织中P-gp、GST-π和TopoⅡ表达阳性率分别为91.9%(34/37)、86.5%(32/37)和21.6%(8/37)。TopoⅡ的表达与肿瘤的分化程度呈负相关。结论:P-gp、GST-π和TopoII在涎腺黏液表皮样癌的多药耐药机制具有重要作用。检测P-gp、GST-π和TopoⅡ可为临床拟定化疗方案提供依据,也可作为判断涎腺黏液表皮样癌预后的参考。
Objective： To investigate the clinical significance of P-glycoprotein,GST π and TopoII expression in mucoepidermoid carcinoma of the salivary glands.Methods： The expression of P-glycoprotein、GST π and TopoII in 37 cases of epidermoid carcinoma and 12 cases of normal salivary glands was detected immuohistochemically by SP method.Results： P-glycoprotein,GST π and TopoⅡ expression was found in both mucoepidermoid carcinoma and normal salivary glands.The positive rates of P-glycoprotein,GST π and TopoⅡin mucoepidermoid carcinoma of salivary glands were 91.9%（34 /37）,86.5%（32 /37）,21.6%（8 /37）.There was a negative correlation between the expression of TopoⅡ and degree of differentiation.Conclusion： P-glycoprotein,GST π and TopoⅡ play an important role in the multidrug resistance in epidermoid carcinoma of the salivary glands.P-glycoprotein,GST-π and TopoⅡ detection may be helpful to chemotherapy and should also be considered as a significant indicator of prognosis in epidermoid carcinoma of the salivary glands.
出处
《现代肿瘤医学》
CAS
2012年第4期698-701,共4页
Journal of Modern Oncology
