摘要
目的观察糖肝康方对糖尿病脂肪肝患者的治疗作用及其对血清瘦素水平的影响。方法在随机、对照的临床试验中,将糖尿病脂肪肝患者随机分为治疗组57例和对照组55例,治疗组采用糖肝康方治疗,对照组采用降糖甲合肌苷治疗,随访8周,观察空腹血糖、餐后2 h血糖、糖化血红蛋白(HbA1c)、血脂、胰岛素敏感性、肝脏B超等有效性指标,并评价其血清瘦素水平。结果糖肝康方可明显降低糖尿病脂肪肝患者的血糖、血脂水平,改善肝脏B超情况,提高胰岛素敏感性,还可调节血清瘦素水平,临床疗效明显。结论糖肝康方可有效治疗糖尿病脂肪肝患者,其作用机制与调节血糖代谢、血脂代谢及瘦素水平密切相关。
Objective To observe the therapeutic effect of Tanggankang Recipe on diabetic patients with fatty liver and its effect on the serum leptin level.Methods 112 diabetic patients with fatty liver were randomly divided into the treatment group（57 patients） and the control group（55 patients）.Patients in the treatment group were treated with Tanggankang Recipe.Patients in the control group were given Jiangtangjia Tablets and Inosine Tablets.All the patients were followed for 8 weeks to assess the parameters of fasting and postprandial blood glucose,HbA1c,blood lipid,insulin sensitivity,liver B-ultrasound and the serum leptin level.Results Tanggankang Recipe significantly reduced the blood glucose and blood lipid levels,and improved the B ultrasonic images and insulin sensitivity in diabetic patients with fatty liver.It also could apparently and safely regulate the serum leptin level.Conclusion Tanggankang Recipe is effective in the treatment of diabetic patients with fatty liver,and the mechanism is closely correlated with the regulation of blood glucose metabolism,blood lipid metabolism and leptin levels.
出处
《山东大学学报（医学版）》
CAS
北大核心
2012年第4期10-14,共5页
Journal of Shandong University:Health Sciences
基金
山东省中医药科技发展计划项目(2011-038)
山东省科学技术发展计划课题(003130130)
关键词
糖肝康方
糖尿病脂肪肝
有效性
胰岛素抵抗
瘦素
Tanggankang Recipe
Diabetes-fatty liver
Efficacy
Insulin sensitivity
Leptin
