摘要
目的 观察抗肿瘤药物丝裂霉素 (MMC)、西艾克 (VDS)和顺铂 (PDD)组成的MVP方案和若维本 (NVB)顺铂 (PDD)组成的NP方案治疗晚期非小细胞肺癌的近期疗效和毒性反应。方法 治疗晚期非小细胞肺癌123例 ,用MVP方案治疗72例 ,用NP方案治疗51例 ,比较毒副反应及疗效。结果 有效率MVP组为43.5 % ,NP组为49.0 % ,两组比较有效率相近 (X2 =0.43P>0.05)。毒副反应主要为骨髓抑制、白细胞下降II-IV级 ,MVP组占84.7% ,NP组占60.8% (X2=9.07P<0.01) ,前者较后者更为严重。其次为胃肠道反应和脱发 ,二者相仿。结论 MVP和NP方案是治疗晚期非小细胞肺癌的有效方案 ,但MVP组的骨髓抑制较NP组更为严重 ,因此治疗晚期非小细胞肺癌用NP方案更为理想。
Objective TO observe the short-term effect and the toxicities of mitonycin,vindesine and cisplatin(MVP) in comparewith vinorelbine and cisplatin(NP) in the treatment of advanced non-small cell lung cancer. Methods one hundred and twenty three patients with non-small cell lung cancer were treated by either MVP regimen(n=72) or NP regimen(n=51).MVP regimen:MMC 6mg/M2 iv day 1,vindesine 3mg/M2 iv days 1,8, cisplatin 40mg/M2 iv days 1,8, cisplatin 40mg iv infusion days 1～3. Results The overall response rate was 43.05% in MVP group and 49.0% in NP group.There was no signi-ficant difference in response rate between these two groups(X2=0.43,P>0.05).The main toxicity was myelosuppression including apparent decrease of WBC and platlets ,which occurred in 84.7% of patients in MVP group,and 60.8% in NP group(X2=9.07,P<0.01).Minor toxicities such as GI reaction ahd alopecia occurred in similar frequehcy between the two groups. Conclusion MVP and NP regimens were both effective in treating advanced non-small cell lung cancer.However,myelosuppression was more pronounced in MVP group than in NP group.NP regimen was more preferable in the treatment of advanced non-small cell lung cancer.
出处
《浙江临床医学》
2000年第3期159-160,共2页
Zhejiang Clinical Medical Journal
关键词
晚期
非小细胞肺癌
治疗
advanced non-small cell lung cancer chemothereapy, curative effect.
