摘要
目的分析恶性肿瘤患者放疗后真菌感染的菌种分布特征及药物耐药性。方法送检2009年9月至2011年8月我院120例恶性肿瘤放疗后患者血液、尿液、胸腹水及痰液样本,对真菌培养及药敏试验结果进行分析。结果 120例恶性肿瘤患者共计检查出33株真菌,阳性率达27.5%,其中最常见为白色念球菌(78.8%),其次是热带念球菌(9.1%);药敏结果表明,其中酮康啶和益康啶耐药率最高,分别为30.82%和26.51%,其次是制霉菌素(15.81%)和咪康唑(12.26%),伊曲康唑耐药率最低(9.32%)。结论掌握肿瘤患者治疗过程中引起针具感染的病原菌及耐药情况,可以指导临床的合理用药。
Objective To analyze the pathogen distribution of specimens causing fungal infection in cancer patients after chemotherapy and chemotherapy and the risk factors that induce fungal infection,so as to effectively prevent and control the fungal infection Methods A total of 120 samples of sputum effusion,urine,feces and blood,submitted from Sep 2009 to Agu 2011 were performed the fungal culture and the results of drug susceptibility testing were analyzed.Results Check out a total of 120 cases of patients with 33 strains of fungi,the positive rate was 27.5%,of which Candida albicansis most common,accounting for 78.8%,followed by a smooth read cocci 9.1%.All fungi showed high resistance rate to various antifungal agents such as nystatin,miconazole,itraconazole,Especially for nystatin and miconazole the resistance rates were as high as 15.81% and 12.26%.The resistance rates to itraconazole was 9.32%.Conclusion To rationally use antifungal agents according to the results of drug susceptibility tests,prevent the abuse of antibiotics and control cancer patients caused by needles during the treatment and drug resistance of pathogens can guide the rational application of antibiotics in clinics.
出处
《中国医药指南》
2012年第8期368-369,共2页
Guide of China Medicine
关键词
恶性肿瘤患者
真菌感染
放疗
耐药性
Patients with malignant tumors
Fungal infections
Radiotherapy
Resistance
