摘要
目的探讨不同剂量阿托伐他汀对冠心病患者经皮冠状动脉介入术(PCI)后患者血脂和心脏缺血事件的影响。方法选择90例冠心病患者成功PCI后患者,随机分为三组:在常规治疗基础上,分别给予阿托伐他汀20mg/d,40mg/d和80mg/d,观察三组患者用药3个月后血脂、心脏缺血事件和不良反应。结果阿托伐他汀有较好的降脂作用,且随着阿托伐他汀剂量的增加,降脂效果更为明显(P<0.05和0.01);40mg/d组和80mg/d组心脏缺血事件发生率较20mg/d组显著下降(P<0.05)。三组的不良反应发生率差异显著性(P>0.05)。结论阿托伐他汀对冠心病患者PIC术后有明显的血脂降低作用,有预防PCI术后再狭窄的作用,且随剂量的增加疗效增加,无严重的不良反应,有临床应用价值。
Objective To investigate the effects of different doses of atorvastatin on the blood lipids and cardiac ischemic events of patients with coronary heart disease treated with percutaneous coronary intervention（PCI）.Methods 90 cases of coronary heart disease patients with successful PCI,were randomly divided into three groups： combining conventional therapy with atorvastatin 20mg/d,40mg/d and 80mg/d respectively.the blood lipids,cardiac ischemic events and adverse reaction in the three groups of patients were observed after 3 months treatment of atorvastatin.Results The lipid-lowering effect of atorvastatin was good and it was more obvious with increasing the dose of atorvastatin（P〈0.05 and P〈0.01）.Compared with 20mg/d group,the rates of cardiac ischemia event decreased significantly in 40mg/d group and 80mg/d group（P〈0.05）.There were no significant differences in incidence of adverse events in three groups（P〉0.05）.Conclusions The application of atorvastatin in patients with coronary heart disease after PIC can reduce blood lipids significantly and prevent restenosis after PCI.The efficacy increased with increasing the doses of atorvastatin but no serious adverse events.It is worthy of clinical application.
出处
《齐齐哈尔医学院学报》
2012年第3期313-314,共2页
Journal of Qiqihar Medical University
关键词
阿托伐他汀
冠心病
经皮冠状动脉介入术
血脂
Atorvastatin Coronary heart disease Percutaneous coronary intervention（PCI） Blood lipids
